BACKGROUND/AIMS: Previous published data on the differentiated/undifferentiated mixed-type early gastric cancer treated with ESD are scarce. METHODOLOGY: The clinicopathological features of the pure differentiated type and differentiated/undifferentiated mixed type adenocarcinoma in final diagnosis of ESD specimens were investigated in 109 early gastric cancers patients treated with ESD. RESULTS: Of the pure differentiated type (102 patients) and differentiated / undifferentiated mixed type (7 patients) adenocarcinoma, submucosal invasive tumors were detected in 6 (5.9%) and 4 cases (57.1%) (p = 0.017), respectively. The mean tumor size was 10.95 +/- 5.12mm and 22.85 +/- 9.51mm (p = 0.0091), respectively. In the cases diagnosed as moderately differentiated adenocarcinoma by preoperative ESD biopsy, submucosal invasive tumors were detected in 2 (12.5%) and 4 cases (57.1%) (p = 0.038), respectively, and the mean tumor size was 12.50 +/- 5.88mm and 22.85 +/- 9.51mm (p = 0.016), respectively. During a median follow-up period of 30.3 months (range: 7-52 months), there were no recurrences or metastasis in any of the 7 mixed type cases. CONCLUSION: In conclusion, the results of our study suggest that large gastric tumors treated with ESD which are diagnosed as moderately differentiated adenocarcinoma in biopsy specimens potentially contain an undifferentiated component.
BACKGROUND/AIMS: Previous published data on the differentiated/undifferentiated mixed-type early gastric cancer treated with ESD are scarce. METHODOLOGY: The clinicopathological features of the pure differentiated type and differentiated/undifferentiated mixed type adenocarcinoma in final diagnosis of ESD specimens were investigated in 109 early gastric cancerspatients treated with ESD. RESULTS: Of the pure differentiated type (102 patients) and differentiated / undifferentiated mixed type (7 patients) adenocarcinoma, submucosal invasive tumors were detected in 6 (5.9%) and 4 cases (57.1%) (p = 0.017), respectively. The mean tumor size was 10.95 +/- 5.12mm and 22.85 +/- 9.51mm (p = 0.0091), respectively. In the cases diagnosed as moderately differentiated adenocarcinoma by preoperative ESD biopsy, submucosal invasive tumors were detected in 2 (12.5%) and 4 cases (57.1%) (p = 0.038), respectively, and the mean tumor size was 12.50 +/- 5.88mm and 22.85 +/- 9.51mm (p = 0.016), respectively. During a median follow-up period of 30.3 months (range: 7-52 months), there were no recurrences or metastasis in any of the 7 mixed type cases. CONCLUSION: In conclusion, the results of our study suggest that large gastric tumors treated with ESD which are diagnosed as moderately differentiated adenocarcinoma in biopsy specimens potentially contain an undifferentiated component.
Authors: Yang Hee Han; Jong Kyu Park; Jun Sung Kwon; Young Don Kim; Woo Jin Jeong; Sang Jin Lee; Koon Hee Han; Gab Jin Cheon Journal: Clin Endosc Date: 2015-05-29
Authors: Yu Yi Choi; Su Jin Kim; Cheol Woong Choi; Dae Hwan Kang; Hyung Wook Kim; Su Bum Park; Hyeong Seok Nam Journal: Medicine (Baltimore) Date: 2016-05 Impact factor: 1.889
Authors: Dae G Ryu; Cheol W Choi; Dae H Kang; Hyung W Kim; Su B Park; Su J Kim; Hyeong S Nam Journal: Medicine (Baltimore) Date: 2017-09 Impact factor: 1.889