| Literature DB >> 20422852 |
H D de Boer1, J van Egmond, J J Driessen, L H J D Booij.
Abstract
A neuromuscular blocking drug (NMBD) induced neuromuscular blockade (NMB) in patients with myasthenia gravis usually dissipates either spontaneously or by administration of neostigmine. We administered sugammadex to a patient with myasthenia gravis to reverse a rocuronium-induced profound NMB. NMBDs predispose such patients to severe postoperative residual paralysis and respiratory complications. Sugammadex binds steroidal NMBDs and, therefore reverses a rocuronium or vecuronium-induced NMB, without interfering with cholinergic transmission. A rapid and complete recovery from profound NMB was achieved and no adverse events were observed. This case suggests that sugammadex is a safe and effective antagonist of a rocuronium induced NMB blockade in patients with myasthenia gravis.Entities:
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Year: 2010 PMID： 20422852 DOI： 10.1016/s0034-9356(10)70194-8
Source DB: PubMed Journal: Rev Esp Anestesiol Reanim ISSN： 0034-9356