| Literature DB >> 20421485 |
Mone Zaidi1, Li Sun, Lisa J Robinson, Irina L Tourkova, Li Liu, Yujuan Wang, Ling-Ling Zhu, Xuan Liu, Jianhua Li, Yuanzhen Peng, Guozhe Yang, Xingming Shi, Alice Levine, Jameel Iqbal, Beatrice B Yaroslavskiy, Carlos Isales, Harry C Blair.
Abstract
We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and the stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the fine vascular network that surrounds highly remodeling bone. We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy.Entities:
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Year: 2010 PMID： 20421485 PMCID： PMC2889316 DOI： 10.1073/pnas.0912176107
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205