Literature DB >> 20421393

Striking species difference in the contribution of concentrative nucleoside transporter 2 to nucleoside uptake between mouse and rat hepatocytes.

Tomomi Furihata1, Yukina Fukuchi, Minami Iikura, Misato Hashizume, Atsushi Miyajima, Miki Nagai, Kan Chiba.   

Abstract

Concentrative nucleoside transporter 2 (CNT2) (encoded by the SLC28A2 gene) transports various antiviral or antitumor purine nucleoside analogs to be involved in their pharmacokinetics and pharmacological actions. The results of our study showed that mouse hepatocytes hardly expressed CNT2 mRNA and no CNT2-dependent nucleoside uptake was observed, while rat hepatocytes exhibited high CNT2-dependent nucleoside uptake activity levels with abundant CNT2 mRNA expression. We concluded that CNT2 contributes considerably to nucleoside uptake in rat hepatocytes but not in mouse hepatocytes.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20421393      PMCID： PMC2897278          DOI： 10.1128/AAC.00010-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

Review 1.  Preparation of isolated rat liver cells.

Authors:  P O Seglen
Journal:  Methods Cell Biol       Date:  1976       Impact factor: 1.441

2.  Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization.

Authors:  J Wang; S F Su; M J Dresser; M E Schaner; C B Washington; K M Giacomini
Journal:  Am J Physiol       Date:  1997-12

3.  Characterization of ribavirin uptake systems in human hepatocytes.

Authors:  Yukina Fukuchi; Tomomi Furihata; Misato Hashizume; Minami Iikura; Kan Chiba
Journal:  J Hepatol       Date:  2010-02-04       Impact factor: 25.083

4.  Differential expression and regulation of nucleoside transport systems in rat liver parenchymal and hepatoma cells.

Authors:  B del Santo; R Valdés; J Mata; A Felipe; F J Casado; M Pastor-Anglada
Journal:  Hepatology       Date:  1998-12       Impact factor: 17.425

5.  The disposition and metabolism of tiazofurin in rodents, rabbits, and dogs.

Authors:  S T Arnold; H N Jayaram; G R Harper; C L Litterst; L Malspeis; J J DeSouza; A E Staubus; G S Ahluwalia; Y A Wilson; D A Cooney
Journal:  Drug Metab Dispos       Date:  1984 Mar-Apr       Impact factor: 3.922

6.  Facilitated diffusion and sodium-dependent transport of purine and pyrimidine nucleosides in rat liver.

Authors:  A Holstege; H M Gengenbacher; L Jehle; J Hoppmann
Journal:  Hepatology       Date:  1991-08       Impact factor: 17.425

Review 7.  Mammalian nucleoside transporters.

Authors:  Wei Kong; Karen Engel; Joanne Wang
Journal:  Curr Drug Metab       Date:  2004-02       Impact factor: 3.731

8.  Preclinical pharmacology and pharmacokinetics of the anti-hepatitis virus agent 2'-fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil in mice and rats.

Authors:  X B Kong; P Vidal; W P Tong; J Chiang; C A Gloff; T C Chou
Journal:  Antimicrob Agents Chemother       Date:  1992-07       Impact factor: 5.191

9.  Hepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver.

Authors:  Tomomi Furihata; Masakiyo Hosokawa; Mio Masuda; Tetsuo Satoh; Kan Chiba
Journal:  Arch Biochem Biophys       Date:  2006-02-09       Impact factor: 4.013

10.  Role of CNT3 in the transepithelial flux of nucleosides and nucleoside-derived drugs.

Authors:  Ekaitz Errasti-Murugarren; Marçal Pastor-Anglada; F Javier Casado
Journal:  J Physiol       Date:  2007-04-05       Impact factor: 5.182
View more
  2 in total

Review 1.  How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion.

Authors:  Douglas B Kell; Stephen G Oliver
Journal:  Front Pharmacol       Date:  2014-10-31       Impact factor: 5.810

2.  CD4+FoxP3+CD73+ regulatory T cell promotes cardiac healing post-myocardial infarction.

Authors:  Rulin Zhuang; Qingshu Meng; Xiaoxue Ma; Shanshan Shi; Shiyu Gong; Jing Liu; Mimi Li; Wenchao Gu; Dan Li; Xumin Zhang; Zhulin Wang; Xinyu Ge; Jiayou Tang; Fang Lin; Xiaoting Liang; Liang Zheng; Zhongmin Liu; Xiaohui Zhou
Journal:  Theranostics       Date:  2022-03-06       Impact factor: 11.600
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.