BACKGROUND: Recent studies have suggested that inflammation may play an important role in aging and the development of disabilities, but knowledge about its importance in the development of muscle weakness and functional disabilities in very old people is limited. This study examined associations between inflammatory markers and physical performance among nonagenarians. METHODS: The population-based sample consisted of 197 women and 65 men aged 90 years. Physical performance was assessed according to the Barthel Index, the chair stand, and handgrip strength. Plasma levels of interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1Ra), and C-reactive protein (CRP) were determined. RESULTS: A gender-adjusted linear regression model showed that high levels of CRP, IL-6, and IL-1Ra were significantly associated with poor handgrip strength (p = .041, p = .023, p < .001, respectively). After adjustment for diseases, smoking and physical exercise high levels of IL-6 and IL-1Ra were still significantly associated with poor hand grip strength (p = .048, p = .004, respectively). In the gender-adjusted model, high levels of CRP, IL-6, and IL-1Ra were significantly associated with a worse Barthel Index (p = .009, p = .004, p = .004, respectively). High levels of CRP and IL-6 were still significantly associated with a worse Barthel Index after adjusted for diseases, smoking and physical exercise (p = .034, p = .041, respectively). In the chair stand, no significant association with inflammatory markers was found. CONCLUSIONS: Associations between high levels of inflammatory markers and worse handgrip strength as well as a worse Barthel Index result were evident among nonagenarians. However, the association with the chair stand was not significant.
BACKGROUND: Recent studies have suggested that inflammation may play an important role in aging and the development of disabilities, but knowledge about its importance in the development of muscle weakness and functional disabilities in very old people is limited. This study examined associations between inflammatory markers and physical performance among nonagenarians. METHODS: The population-based sample consisted of 197 women and 65 men aged 90 years. Physical performance was assessed according to the Barthel Index, the chair stand, and handgrip strength. Plasma levels of interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1Ra), and C-reactive protein (CRP) were determined. RESULTS: A gender-adjusted linear regression model showed that high levels of CRP, IL-6, and IL-1Ra were significantly associated with poor handgrip strength (p = .041, p = .023, p < .001, respectively). After adjustment for diseases, smoking and physical exercise high levels of IL-6 and IL-1Ra were still significantly associated with poor hand grip strength (p = .048, p = .004, respectively). In the gender-adjusted model, high levels of CRP, IL-6, and IL-1Ra were significantly associated with a worse Barthel Index (p = .009, p = .004, p = .004, respectively). High levels of CRP and IL-6 were still significantly associated with a worse Barthel Index after adjusted for diseases, smoking and physical exercise (p = .034, p = .041, respectively). In the chair stand, no significant association with inflammatory markers was found. CONCLUSIONS: Associations between high levels of inflammatory markers and worse handgrip strength as well as a worse Barthel Index result were evident among nonagenarians. However, the association with the chair stand was not significant.
Authors: David de Gonzalo-Calvo; Benjamín Fernández-García; Beatriz de Luxán-Delgado; Susana Rodríguez-González; Marina García-Macia; Francisco Manuel Suárez; Juan José Solano; María Josefa Rodríguez-Colunga; Ana Coto-Montes Journal: Age (Dordr) Date: 2012-01-04
Authors: David de Gonzalo-Calvo; Benjamín Fernández-García; Beatriz de Luxán-Delgado; Susana Rodríguez-González; Marina García-Macia; Francisco Manuel Suárez; Juan José Solano; María Josefa Rodríguez-Colunga; Ana Coto-Montes Journal: Age (Dordr) Date: 2011-06-04
Authors: Daniele Sirineu Pereira; Elvis Cristian Cueva Mateo; Bárbara Zille de Queiroz; Alexandra Miranda Assumpção; Aline Silva Miranda; Diogo Carvalho Felício; Natália Pessoa Rocha; Daniela Maria da Cruz dos Anjos; Danielle Aparecida Gomes Pereira; Antonio Lucio Teixeira; Leani Souza Máximo Pereira Journal: Age (Dordr) Date: 2013-02-21
Authors: Candace L Crasto; Richard D Semba; Kai Sun; Mansi Dalal; Anna Maria Corsi; Stefania Bandinelli; Jack M Guralnik; Luigi Ferrucci Journal: J Gerontol A Biol Sci Med Sci Date: 2011-02-28 Impact factor: 6.053
Authors: Candace K McClure; Samar R El Khoudary; Carrie A Karvonen-Gutierrez; Kelly R Ylitalo; Kristin Tomey; Trang VoPham; Barbara Sternfeld; Jane A Cauley; Siobán Harlow Journal: Exp Gerontol Date: 2013-11-07 Impact factor: 4.032