OBJECTIVE: Biomarkers may be helpful in screening patients with psoriasis for PsA. Our purpose was to identify serum biomarkers for psoriasis and PsA. METHODS: Fifty-two patients with psoriasis (26 satisfying CASPAR classification criteria for PsA) and 26 healthy controls were recruited for our study. Patients with psoriasis and PsA were group matched for age, sex and psoriasis duration, whereas controls were matched for age and sex. Blood samples were drawn at the time of assessment and serum was analysed for the following: IL-12, IL-12p40, IL-17, TNF super family member 14 (TNFSF14), MMP-3, RANK ligand (RANKL), osteoprotegerin (OPG), cartilage oligomeric matrix protein (COMP), C-propeptide of Type II collagen (CPII), collagen fragment neoepitopes Col2-3/4(long mono) (C2C) and Col2-3/4(short) (C1-2C) and highly sensitive CRP (hsCRP). Data were analysed using logistic regression and receiver operating characteristic curves were plotted. RESULTS: Fifty-two patients with psoriatic disease had a mean age of 46 years and psoriasis duration of 16.8 years. Compared with controls, increased serum levels of RANKL, TNFSF14, MMP-3 and COMP independently associated with psoriatic disease (P < 0.05). Twenty-six PsA patients (mean swollen and/or tender joint count 16, swollen joint count 5) were then compared with 26 patients who had psoriasis alone. Increased levels of hsCRP, OPG, MMP-3 and the CPII : C2C ratio were independently associated with PsA (P < 0.03). CONCLUSION: This pilot study indicates that hsCRP, OPG, MMP-3 and the CPII : C2C ratio are biomarkers for PsA in patients with psoriasis.
OBJECTIVE: Biomarkers may be helpful in screening patients with psoriasis for PsA. Our purpose was to identify serum biomarkers for psoriasis and PsA. METHODS: Fifty-two patients with psoriasis (26 satisfying CASPAR classification criteria for PsA) and 26 healthy controls were recruited for our study. Patients with psoriasis and PsA were group matched for age, sex and psoriasis duration, whereas controls were matched for age and sex. Blood samples were drawn at the time of assessment and serum was analysed for the following: IL-12, IL-12p40, IL-17, TNF super family member 14 (TNFSF14), MMP-3, RANK ligand (RANKL), osteoprotegerin (OPG), cartilage oligomeric matrix protein (COMP), C-propeptide of Type II collagen (CPII), collagen fragment neoepitopes Col2-3/4(long mono) (C2C) and Col2-3/4(short) (C1-2C) and highly sensitive CRP (hsCRP). Data were analysed using logistic regression and receiver operating characteristic curves were plotted. RESULTS: Fifty-two patients with psoriatic disease had a mean age of 46 years and psoriasis duration of 16.8 years. Compared with controls, increased serum levels of RANKL, TNFSF14, MMP-3 and COMP independently associated with psoriatic disease (P < 0.05). Twenty-six PsA patients (mean swollen and/or tender joint count 16, swollen joint count 5) were then compared with 26 patients who had psoriasis alone. Increased levels of hsCRP, OPG, MMP-3 and the CPII : C2C ratio were independently associated with PsA (P < 0.03). CONCLUSION: This pilot study indicates that hsCRP, OPG, MMP-3 and the CPII : C2C ratio are biomarkers for PsA in patients with psoriasis.
Authors: Jose U Scher; Carles Ubeda; Alejandro Artacho; Mukundan Attur; Sandrine Isaac; Soumya M Reddy; Shoshana Marmon; Andrea Neimann; Samuel Brusca; Tejas Patel; Julia Manasson; Eric G Pamer; Dan R Littman; Steven B Abramson Journal: Arthritis Rheumatol Date: 2015-01 Impact factor: 10.995
Authors: Heidi Lausten Munk; Natasja Staehr Gudmann; Anne Friesgaard Christensen; Leif Ejstrup; Grith Lykke Sorensen; Anne Gitte Loft; Anne C Bay-Jensen; Anne Sofie Siebuhr; Peter Junker Journal: Rheumatol Int Date: 2015-11-30 Impact factor: 2.631
Authors: So Yeon Paek; Ling Han; Matthew Weiland; Chuan-Jian Lu; Kathleen McKinnon; Li Zhou; Henry W Lim; James T Elder; Qing-Sheng Mi Journal: IUBMB Life Date: 2015-11-24 Impact factor: 3.885
Authors: M Puato; R Ramonda; A Doria; M Rattazzi; E Faggin; G Balbi; M Zanon; M Zanardo; C Tirrito; M Lorenzin; V Modesti; M Plebani; M Zaninotto; L Punzi; P Pauletto Journal: J Hum Hypertens Date: 2013-07-11 Impact factor: 3.012