Literature DB >> 20420395

A one-step synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid esters from o-nitrobenzaldehydes.

Hariharan Venkatesan1, Frances M Hocutt, Todd K Jones, Michael H Rabinowitz.   

Abstract

A straightforward and efficient one-step procedure for the synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters is described. The simple reductive cyclization is carried out by treating various substituted o-nitrobenzaldehydes with inexpensive, commercially available 3,3-diethoxypropionic acid ethyl ester and SnCl(2).2H(2)O in refluxing ethanol.

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Year:  2010        PMID： 20420395     DOI： 10.1021/jo100392x

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

1.  Facile Synthesis and Photophysical Characterization of New Quinoline Dyes.

Authors:  Giovanny Carvalho Dos Santos; Aloisio de Andrade Bartolomeu; Valdecir Farias Ximenes; Luiz Carlos da Silva-Filho
Journal:  J Fluoresc       Date:  2016-10-27       Impact factor: 2.217

2.  First synthesis of novel 2,4-bis((E)-styryl)quinoline-3-carboxylate derivatives and their antitumor activity.

Authors:  Wentao Gao; Zhiyuan Li; Qiqi Xu; Yang Li
Journal:  RSC Adv       Date:  2018-11-19       Impact factor: 4.036

3.  Synthesis of quinoline-3-carboxylates by a Rh(II)-catalyzed cyclopropanation-ring expansion reaction of indoles with halodiazoacetates.

Authors:  Magnus Mortén; Martin Hennum; Tore Bonge-Hansen
Journal:  Beilstein J Org Chem       Date:  2015-10-20       Impact factor: 2.883
  3 in total

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