Literature DB >> 20420382

Multistep microwave-assisted divergent synthesis of indolo-fused pyrazino-/diazepinoquinoxalinones on PEG support.

Jin-Ji Lai1, Deepak B Salunke, Chung-Ming Sun.   

Abstract

Synthesis of amino acid and indoline-substituted dinitrobenzene on a soluble polymer support (PEG) and its further reductive double-ring closure to afford structurally diverse indolo-fused pyrazino-/diazepinoquinoxalinones is described. Traceless synthesis of quinoxalinones coupled with application of the Pictet-Spengler-type condensation reaction furnished these novel scaffolds. These hitherto novel heterocycles are synthesized in shorter times under microwave irradiation conditions in comparison with that of classical reaction conditions.

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Year:  2010        PMID： 20420382     DOI： 10.1021/ol100436r

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.

Authors:  Warren R J D Galloway; Albert Isidro-Llobet; David R Spring
Journal:  Nat Commun       Date:  2010-09-21       Impact factor: 14.919

2.  Microwave-assisted synthesis of 5,6-dihydroindolo[1,2-a]quinoxaline derivatives through copper-catalyzed intramolecular N-arylation.

Authors:  Fei Zhao; Lei Zhang; Hailong Liu; Shengbin Zhou; Hong Liu
Journal:  Beilstein J Org Chem       Date:  2013-11-14       Impact factor: 2.883

3.  Determinants of activity at human Toll-like receptors 7 and 8: quantitative structure-activity relationship (QSAR) of diverse heterocyclic scaffolds.

Authors:  Euna Yoo; Deepak B Salunke; Diptesh Sil; Xiaoqiang Guo; Alex C D Salyer; Alec R Hermanson; Manoj Kumar; Subbalakshmi S Malladi; Rajalakshmi Balakrishna; Ward H Thompson; Hiromi Tanji; Umeharu Ohto; Toshiyuki Shimizu; Sunil A David
Journal:  J Med Chem       Date:  2014-09-17       Impact factor: 7.446

4.  Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck-Suzuki reaction.

Authors:  Esther Alza; Luca Laraia; Brett M Ibbeson; Súil Collins; Warren R J D Galloway; Jamie E Stokes; Ashok R Venkitaraman; David R Spring
Journal:  Chem Sci       Date:  2014-09-09       Impact factor: 9.825
  4 in total

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