| Literature DB >> 20417042 |
G Pannone1, F Sanguedolce, A Santoro, P Fierro, M Panetti, D Fierro, F Maiello, S De Maria, A Giannattasio, R Serpico, L Lo Muzio, S Metafora, P Bufo.
Abstract
Human papilloma virus infection is thought to play a role in laryngeal carcinogenesis; the variable association reported in literature may be due to wide range of HPV genotypes. We report the case of a 51-year-old man affected by laryngeal squamous cell carcinoma; analysis of DNA extracted by cancer cells by an innovative molecular virology assay (INNO-LiPA HPV Genotyping Extra) showed the presence of two high-risk HPV genotypes, HPV-73 and -82. Immunohistochemical examination confirmed positivity for both capsid protein and viral oncogenic protein E7. Such association has never been reported in literature so far, and a brief discussion on the importance of assessing HPV status in laryngeal cancer is provided. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20417042 DOI： 10.1016/j.anl.2010.03.003
Source DB: PubMed Journal: Auris Nasus Larynx ISSN： 0385-8146 Impact factor: 1.863