Literature DB >> 2041589

Elevated corticosterone levels in transgenic mice expressing human or bovine growth hormone genes.

M Cecim1, P K Ghosh, A I Esquifino, T Began, T E Wagner, J S Yun, A Bartke.   

Abstract

Ectopic expression of human or bovine growth hormone (GH) genes in 6 lines of transgenic mice was associated with a significant increase in plasma corticosterone levels. Elevated corticosterone levels were detected in both sexes under basal conditions and after ether stress. The adrenal activity of 3 beta-hydroxysteroid dehydrogenase was measured in two of these lines and was found to be significantly increased in transgenic animals. Plasma corticosterone levels in transgenic mice did not correlate with known differences between the various lines in male and female fertility or in the life span.

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Year:  1991        PMID： 2041589     DOI： 10.1159/000125734

Source DB:  PubMed          Journal:  Neuroendocrinology        ISSN： 0028-3835            Impact factor:   4.914


  7 in total

1.  Effects of overexpression of growth hormone-releasing hormone on the hypothalamo-pituitary-gonadal function in the mouse.

Authors:  L Debeljuk; R W Steger; J C Wright; J Mattison; A Bartke
Journal:  Endocrine       Date:  1999-10       Impact factor: 3.633

Review 2.  Adrenocortical carcinoma.

Authors:  Tobias Else; Alex C Kim; Aaron Sabolch; Victoria M Raymond; Asha Kandathil; Elaine M Caoili; Shruti Jolly; Barbra S Miller; Thomas J Giordano; Gary D Hammer
Journal:  Endocr Rev       Date:  2013-12-20       Impact factor: 19.871

3.  Increased plasma corticosterone levels in bovine growth hormone (bGH) transgenic mice: effects of ACTH, GH and IGF-I on in vitro adrenal corticosterone production.

Authors:  M Cecim; M Alvarez-Sanz; L Van de Kar; S Milton; A Bartke
Journal:  Transgenic Res       Date:  1996-05       Impact factor: 2.788

4.  Lactotroph hyperplasia in the pituitaries of female mice expressing high levels of bovine growth hormone.

Authors:  S Vidal; L Stefaneanu; K Thapar; R Aminyar; K Kovacs; A Bartke
Journal:  Transgenic Res       Date:  1999-06       Impact factor: 2.788

5.  Effects of overexpression of growth hormone on T cell activity in transgenic mice.

Authors:  A I Esquifino; A Arce; M P Alvarez; A Szary; H Brown-Borg; A Bartke
Journal:  J Physiol Biochem       Date:  2002-09       Impact factor: 4.158

6.  Maternal dietary restriction during the periconceptional period in normal-weight or obese ewes results in adrenocortical hypertrophy, an up-regulation of the JAK/STAT and down-regulation of the IGF1R signaling pathways in the adrenal of the postnatal lamb.

Authors:  Song Zhang; Janna L Morrison; Amreet Gill; Leewen Rattanatray; Severence M MacLaughlin; David Kleemann; Simon K Walker; I Caroline McMillen
Journal:  Endocrinology       Date:  2013-10-09       Impact factor: 4.736

Review 7.  Growth hormone and aging.

Authors:  A Bartke
Journal:  Endocrine       Date:  1998-04       Impact factor: 3.925
  7 in total

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