BACKGROUND: Few data on the effect of human papillomavirus (HPV) infection on human immunodeficiency virus (HIV) acquisition are available. METHODS:HIV-seronegative, sexually active, 18-24-year-old Kenyan men participating in a randomized trial of male circumcision provided exfoliated penile cells from 2 anatomical sites (glans/coronal sulcus and shaft) at baseline. The GP5+/6+ polymerase chain reaction assay ascertained a wide range of HPV DNA types at the baseline visit. The risk of HIV infection was estimated using Kaplan-Meier methods and hazard ratios from proportional hazards models. RESULTS: Of 2168 uncircumcised men with baseline HPV data, 1089 (50%) were positive for HPV DNA. The cumulative incidence of HIV infection by 42 months was 5.8% (95% confidence interval [CI], 3.6%-7.9%) among men with HPV-positive glans/coronal sulcus specimens, versus 3.7% [95% CI, 1.8%-5.6%] among men with HPV-negative glans/coronal sulcus specimens (P = .01). Controlling for subsequent circumcision status, baseline herpes simplex virus type 2 serostatus, and sexual and sociodemographic risk factors, the hazard ratio for HIV infection among men with HPV-positive glans/coronal sulcus specimens was 1.8 (95% CI, 1.1-2.9), compared with men with HPV-negative glans/coronal sulcus specimens. CONCLUSION: The results suggest an independent increased risk of HIV seroconversion among HPV-positive men. If this finding is confirmed in other studies, HPV prevention could be another tool for HIV prevention.
RCT Entities:
BACKGROUND: Few data on the effect of humanpapillomavirus (HPV) infection on human immunodeficiency virus (HIV) acquisition are available. METHODS:HIV-seronegative, sexually active, 18-24-year-old Kenyan men participating in a randomized trial of male circumcision provided exfoliated penile cells from 2 anatomical sites (glans/coronal sulcus and shaft) at baseline. The GP5+/6+ polymerase chain reaction assay ascertained a wide range of HPV DNA types at the baseline visit. The risk of HIV infection was estimated using Kaplan-Meier methods and hazard ratios from proportional hazards models. RESULTS: Of 2168 uncircumcised men with baseline HPV data, 1089 (50%) were positive for HPV DNA. The cumulative incidence of HIV infection by 42 months was 5.8% (95% confidence interval [CI], 3.6%-7.9%) among men with HPV-positive glans/coronal sulcus specimens, versus 3.7% [95% CI, 1.8%-5.6%] among men with HPV-negative glans/coronal sulcus specimens (P = .01). Controlling for subsequent circumcision status, baseline herpes simplex virus type 2 serostatus, and sexual and sociodemographic risk factors, the hazard ratio for HIV infection among men with HPV-positive glans/coronal sulcus specimens was 1.8 (95% CI, 1.1-2.9), compared with men with HPV-negative glans/coronal sulcus specimens. CONCLUSION: The results suggest an independent increased risk of HIV seroconversion among HPV-positive men. If this finding is confirmed in other studies, HPV prevention could be another tool for HIV prevention.
Authors: Annemieke de Jong; Sjoerd H van der Burg; Kitty M C Kwappenberg; Jeanette M van der Hulst; Kees L M C Franken; Annemieke Geluk; Krista E van Meijgaarden; Jan Wouter Drijfhout; Gemma Kenter; Pieter Vermeij; Cornelis J M Melief; Rienk Offringa Journal: Cancer Res Date: 2002-01-15 Impact factor: 12.701
Authors: Adriaan J C van den Brule; René Pol; Nathalie Fransen-Daalmeijer; Leo M Schouls; Chris J L M Meijer; Peter J F Snijders Journal: J Clin Microbiol Date: 2002-03 Impact factor: 5.948
Authors: N Coleman; H D Birley; A M Renton; N F Hanna; B K Ryait; M Byrne; D Taylor-Robinson; M A Stanley Journal: Am J Clin Pathol Date: 1994-12 Impact factor: 2.493
Authors: Qingsheng Li; Jacob D Estes; Patrick M Schlievert; Lijie Duan; Amanda J Brosnahan; Peter J Southern; Cavan S Reilly; Marnie L Peterson; Nancy Schultz-Darken; Kevin G Brunner; Karla R Nephew; Stefan Pambuccian; Jeffrey D Lifson; John V Carlis; Ashley T Haase Journal: Nature Date: 2009-03-04 Impact factor: 49.962
Authors: Maaike C G Bleeker; Cornelis J A Hogewoning; Adriaan J C Van Den Brule; Feja J Voorhorst; Rick E Van Andel; Elle K J Risse; Theo M Starink; Chris J L M Meijer Journal: J Am Acad Dermatol Date: 2002-09 Impact factor: 11.527
Authors: Iain J Macleod; Belinda O'Donnell; Sikhulile Moyo; Shahin Lockman; Roger L Shapiro; Mukendi Kayembe; Erik van Widenfelt; Joseph Makhema; M Essex; Carolyn Wester Journal: J Med Virol Date: 2011-10 Impact factor: 2.327
Authors: Anne F Rositch; Charles Poole; Michael G Hudgens; Kawango Agot; Edith Nyagaya; Stephen Moses; Peter J F Snijders; Chris J L M Meijer; Robert C Bailey; Jennifer S Smith Journal: J Infect Dis Date: 2011-11-04 Impact factor: 5.226
Authors: Sten H Vermund; José A Tique; Holly M Cassell; Megan E Pask; Philip J Ciampa; Carolyn M Audet Journal: J Acquir Immune Defic Syndr Date: 2013-06-01 Impact factor: 3.731
Authors: Aaron A R Tobian; Mary K Grabowski; Godfrey Kigozi; Andrew D Redd; Kevin P Eaton; David Serwadda; Toby C Cornish; Fred Nalugoda; Stephen Watya; Denis Buwembo; James Nkale; Maria J Wawer; Thomas C Quinn; Ronald H Gray Journal: J Infect Dis Date: 2013-01-23 Impact factor: 5.226
Authors: Frank Tanser; Kyle G Jones; Johannes Viljoen; John Imrie; Erofili Grapsa; Marie-Louise Newell Journal: Sex Transm Dis Date: 2013-07 Impact factor: 2.830