Literature DB >> 20415465

A novel diastereoselective multicomponent cascade reaction.

Kadri Kriis1, Kerti Ausmees, Tõnis Pehk, Margus Lopp, Tõnis Kanger.   

Abstract

A novel multicomponent cascade reaction led to the formation of a strained 3-azabicyclo[3.2.0]heptane derivative 4. The unstable ester 4 was reduced in a one-pot procedure to a stable alcohol 6. The formation of the bicyclic product is highly diastereoselective, predominantly affording one diastereoisomer. The obtained azabicycloheptanes are important pharmacophores.

Entities:  

Year:  2010        PMID： 20415465     DOI： 10.1021/ol1005714

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Theoretical study of the mechanism of highly diastereoselective formation of a strained 3-azabicyclo[3.2.0]heptane derivative.

Authors:  Maryam Nemati; Nematollah Arshadi
Journal:  J Mol Model       Date:  2015-03-14       Impact factor: 1.810

2.  Enantioselective approach to quinolizidines: total synthesis of cermizine D and formal syntheses of senepodine G and cermizine C.

Authors:  Nagarathanam Veerasamy; Erik C Carlson; Nathan D Collett; Mrinmoy Saha; Rich G Carter
Journal:  J Org Chem       Date:  2013-04-29       Impact factor: 4.354

3.  One-pot synthesis of novel 1-(1H-tetrazol-5-yl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine derivatives via an Ugi-azide 4CR process.

Authors:  Mehdi Ghandi; Saleh Salahi; Abuzar Taheri; Alireza Abbasi
Journal:  Mol Divers       Date:  2017-12-11       Impact factor: 2.943
  3 in total

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