PURPOSE OF REVIEW: Human parechoviruses (HPeVs) within the large and growing family of Picornaviridaeare common human pathogens associated with a wide spectrum of disease presentations. Although 10 different HPeV types have been published to date, there is increasing evidence for a specific role of HPeV type 3 (HPeV3) in severe neonatal disease. In this review, we will describe both the disease associations and underlying epidemiological and/or biological basis for the often marked differences in disease outcomes between HPeV types. RECENT FINDINGS: Application of molecular-based diagnostic techniques has revealed an association between neonatal sepsis, encephalitis and hepatitis with HPeV3 but not with other parechovirus types. HPeV3 shows evidence for very recent emergence in human populations as well as inferred differences in cellular receptor usage. SUMMARY: The recently discovered HPeV3 has been shown to play an important role in severe neonatal infections, observations possibly linked to its very recent emergence or possibly different cellular tropism that underlie its targeting of the most susceptible individuals. HPeV infections are currently under-diagnosed and should be considered in the clinical and diagnostic evaluation of severe neonatal disease presentations.
PURPOSE OF REVIEW: Human parechoviruses (HPeVs) within the large and growing family of Picornaviridaeare common human pathogens associated with a wide spectrum of disease presentations. Although 10 different HPeV types have been published to date, there is increasing evidence for a specific role of HPeV type 3 (HPeV3) in severe neonatal disease. In this review, we will describe both the disease associations and underlying epidemiological and/or biological basis for the often marked differences in disease outcomes between HPeV types. RECENT FINDINGS: Application of molecular-based diagnostic techniques has revealed an association between neonatal sepsis, encephalitis and hepatitis with HPeV3 but not with other parechovirus types. HPeV3 shows evidence for very recent emergence in human populations as well as inferred differences in cellular receptor usage. SUMMARY: The recently discovered HPeV3 has been shown to play an important role in severe neonatal infections, observations possibly linked to its very recent emergence or possibly different cellular tropism that underlie its targeting of the most susceptible individuals. HPeV infections are currently under-diagnosed and should be considered in the clinical and diagnostic evaluation of severe neonatal disease presentations.
Authors: W Allan Nix; Nino Khetsuriani; Silvia Peñaranda; Kaija Maher; Linda Venczel; Zsuzsa Cselkó; Maria Cecilia Freire; Daniel Cisterna; Cristina L Lema; Patricia Rosales; Jacqueline R Rodriguez; Wilma Rodriguez; Percy Halkyer; Olivier Ronveaux; Mark A Pallansch; M Steven Oberste Journal: J Gen Virol Date: 2013-06-26 Impact factor: 3.891
Authors: Eric Rhoden; Terry Fei Fan Ng; Ray Campagnoli; W Allan Nix; Jennifer Konopka-Anstadt; Rangaraj Selvarangan; Laurence Briesach; M Steven Oberste; William C Weldon Journal: Antimicrob Agents Chemother Date: 2020-02-21 Impact factor: 5.191
Authors: Susan Bennett; Heli Harvala; Jeroen Witteveldt; E Carol McWilliam Leitch; Nigel McLeish; Kate Templeton; Rory Gunson; William F Carman; Peter Simmonds Journal: J Clin Microbiol Date: 2011-05-18 Impact factor: 5.948
Authors: Anna M Eis-Hübinger; Isabella Eckerle; Angelika Helmer; Ulrike Reber; Till Dresbach; Stephan Buderus; Christian Drosten; Andreas Müller Journal: J Clin Microbiol Date: 2012-12-12 Impact factor: 5.948