OBJECTIVE: Pharmacists are commonly confronted with patients with a history of sulfonamide allergy. Basic immunologic and clinical data suggest a low likelihood of a patient with a history of sulfonamide hypersensitivity developing an allergic reaction to a non-antimicrobial sulfonamide drug. We conducted a survey to describe the knowledge and attitudes of licensed pharmacists concerning sulfonamide allergy cross-reactivity. METHODS: A survey instrument was developed and sent to all licensed pharmacists in the state of Iowa. The survey recorded demographic information and included six patient scenarios designed to elicit responses concerning sulfonamide allergy cross-reactivity with a number of non-antimicrobial sulfonamides. RESULTS: A total of 421 surveys were returned for a 39% response rate. There was a wide discrepancy in approaches to patients with a history of sulfonamide allergy prescribed a sulfonamide containing non-antibiotic. Differences depended on previous history of tolerating the medication in question, the degree of cautionary statements in product literature, and the familiarity the pharmacist had with the product. CONCLUSION: Our survey suggests a significant diversity in knowledge and attitudes of pharmacists concerning cross-reactivity of sulfonamide antimicrobials and other drugs with a sulfonamide moiety. Depth of training in this area may be an associative factor.
OBJECTIVE: Pharmacists are commonly confronted with patients with a history of sulfonamideallergy. Basic immunologic and clinical data suggest a low likelihood of a patient with a history of sulfonamidehypersensitivity developing an allergic reaction to a non-antimicrobial sulfonamide drug. We conducted a survey to describe the knowledge and attitudes of licensed pharmacists concerning sulfonamideallergy cross-reactivity. METHODS: A survey instrument was developed and sent to all licensed pharmacists in the state of Iowa. The survey recorded demographic information and included six patient scenarios designed to elicit responses concerning sulfonamideallergy cross-reactivity with a number of non-antimicrobial sulfonamides. RESULTS: A total of 421 surveys were returned for a 39% response rate. There was a wide discrepancy in approaches to patients with a history of sulfonamideallergy prescribed a sulfonamide containing non-antibiotic. Differences depended on previous history of tolerating the medication in question, the degree of cautionary statements in product literature, and the familiarity the pharmacist had with the product. CONCLUSION: Our survey suggests a significant diversity in knowledge and attitudes of pharmacists concerning cross-reactivity of sulfonamide antimicrobials and other drugs with a sulfonamide moiety. Depth of training in this area may be an associative factor.
Authors: John Farrell; Dean J Naisbitt; Nicola S Drummond; Jan P H Depta; F Javier Vilar; Munir Pirmohamed; B Kevin Park Journal: J Pharmacol Exp Ther Date: 2003-04-03 Impact factor: 4.030
Authors: Jeffrey L Schnipper; Jennifer L Kirwin; Michael C Cotugno; Stephanie A Wahlstrom; Brandon A Brown; Emily Tarvin; Allen Kachalia; Mark Horng; Christopher L Roy; Sylvia C McKean; David W Bates Journal: Arch Intern Med Date: 2006-03-13
Authors: Brian L Strom; Rita Schinnar; Andrea J Apter; David J Margolis; Ebbing Lautenbach; Sean Hennessy; Warren B Bilker; Dan Pettitt Journal: N Engl J Med Date: 2003-10-23 Impact factor: 91.245
Authors: Jason A Trubiano; Cosby A Stone; M Lindsay Grayson; Karen Urbancic; Monica A Slavin; Karin A Thursky; Elizabeth J Phillips Journal: J Allergy Clin Immunol Pract Date: 2017-08-23