Literature DB >> 20414459

A combinatorial multicomponent plug mixer for systems chemistry.

F Azizi, Q Wan, T Radivoyevitch, C Dealwis, C H Mastrangelo.   

Abstract

We report the construction and testing of a combinatorial multicomponent plug mixer (CMPM) chip that generates a large number of mix ratios. The CMPM chip has been designed to study ribonucleotide reductase (RNR) protein-protein/protein-ligand interaction networks. The 4-component chip is capable of 5400 different combinations in a 30 plug cycle. CMPM chips were tested producing fluorescent dye and dihydrofolate reductase NADPH/MX mixtures with plug lengths of 2 mm.

Entities:  

Year:  2008        PMID: 20414459      PMCID: PMC2857516     

Source DB:  PubMed          Journal:  Micro Total Anal Syst        ISSN: 1556-5890


  4 in total

1.  Monolithic microfabricated valves and pumps by multilayer soft lithography.

Authors:  M A Unger; H P Chou; T Thorsen; A Scherer; S R Quake
Journal:  Science       Date:  2000-04-07       Impact factor: 47.728

2.  Systems chemistry.

Authors:  R Frederick Ludlow; Sijbren Otto
Journal:  Chem Soc Rev       Date:  2007-09-03       Impact factor: 54.564

3.  Generation of dynamic chemical signals with pulse code modulators.

Authors:  F Azizi; C H Mastrangelo
Journal:  Lab Chip       Date:  2008-04-15       Impact factor: 6.799

4.  Kinetics of ligand binding to dihydrofolate reductase: binary complex formation with NADPH and coenzyme analogues.

Authors:  S M Dunn; J G Batchelor; R W King
Journal:  Biochemistry       Date:  1978-06-13       Impact factor: 3.162

  4 in total

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