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Literature DB >> 20413881

MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study.

Abstract

MiR-107 is a microRNA (miRNA) that we reported previously to have decreased expression in the temporal cortical gray matter early in the progression of Alzheimer's disease (AD). Here we study a new group of well-characterized human temporal cortex samples (N=19). MiR-107 expression was assessed, normalized to miR-124 and let-7a. Correlation was observed between decreased miR-107 expression and increased neuritic plaque counts (P< 0.05) and neurofibrillary tangle counts (P< 0.02) in adjacent brain tissue. Adjusted miR-107 and BACE1 mRNA levels tended to correlate negatively (trend with regression P< 0.07). In sum, miR-107 expression tends to be lower relative to other miRNAs as AD progresses.

Entities: Chemical Disease Gene Species

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Year: 2010 PMID： 20413881 PMCID： PMC2910235 DOI： 10.3233/JAD-2010-091603

Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472

24 in total

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78 in total

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Review 6. Exploring Biomarkers for Alzheimer's Disease.

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Journal: Curr Alzheimer Res Date: 2012-07 Impact factor: 3.498