| Literature DB >> 20413850 |
Geoffroy Laumet1, Vincent Chouraki, Benjamin Grenier-Boley, Vanessa Legry, Simon Heath, Diana Zelenika, Nathalie Fievet, Didier Hannequin, Marc Delepine, Florence Pasquier, Olivier Hanon, Alexis Brice, Jacques Epelbaum, Claudine Berr, Jean-Francois Dartigues, Christophe Tzourio, Dominique Campion, Mark Lathrop, Lars Bertram, Philippe Amouyel, Jean-Charles Lambert.
Abstract
We selected twenty genes from the "Top Results" list on the AlzGene database website and assessed their association with risk of developing Alzheimer's disease (AD) in a large, genome-wide association study (using 526 SNPs from 2,032 AD cases and 5,328 controls) performed in France. The APOE, CLU, PICALM, and CR1 loci were excluded, since they had already been extensively analyzed. Ten genes/loci (TFAM, SORL1, CHRNB2, SORCS1, DAPK1, MTHFR, GWA 14q32.13, BDNF, NEDD9, and CH25H) showed weak nominal association with AD risk, in line with previous studies. In the remaining ten genes/loci (TNK1, ACE, CST3, IL1B, hCG2039140, PRNP, GAB2, LOC651924, IL1A, and TF), no single nucleotide polymorphisms were associated in our dataset. Of the genes showing nominal association in our cohorts, TFAM and CHRNB2 appear particularly interesting and warrant further genetic and functional follow-up analyses.Entities:
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Year: 2010 PMID： 20413850 DOI： 10.3233/JAD-2010-100126
Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472