Literature DB >> 20412794

Preliminary quantitative proteomic characterization of glaucomatous rat retinal ganglion cells.

John W Crabb1, Xianglin Yuan, Galina Dvoriantchikova, Dmitry Ivanov, John S Crabb, Valery I Shestopalov.   

Abstract

Quantitative proteomic analysis was pursued of retinal ganglion cells (RGCs) from rats with unilateral experimental glaucoma. RGCs were isolated from 22 animals by immunopanning after 8 weeks of sustained elevated intraocular pressure. Proteins were quantified by LC MS/MS iTRAQ technology. Of the 268 proteins quantified, approximately 8% appeared elevated and approximately 13% decreased in glaucomatous RGCs. Voltage-dependent anion channel protein 2, aldose reductase, and ubiquitin were among the significantly elevated proteins while prothymosin was among the significantly decreased. The results demonstrate the feasibility of identifying global proteomic differences in protein expression between purified glaucomatous and control in vivo RGCs. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20412794      PMCID： PMC2881315          DOI： 10.1016/j.exer.2010.04.004

Source DB:  PubMed          Journal:  Exp Eye Res        ISSN： 0014-4835            Impact factor:   3.467


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