Literature DB >> 20412378

AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4.

Anapatricia García1, Nagadenahalli B Siddappa, Qingsheng Li, Ashley T Haase, Katherine Paul, Fawn Stroud, Xiaodong Zhang, Jack A Fountain, François Villinger, Francis J Novembre, James G Else, W Evan Secor, Ruth M Ruprecht.   

Abstract

A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4(+) T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.
© 2010 John Wiley & Sons A/S.

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Year:  2010        PMID： 20412378      PMCID： PMC3095218          DOI： 10.1111/j.1600-0684.2010.00416.x

Source DB:  PubMed          Journal:  J Med Primatol        ISSN： 0047-2565            Impact factor:   0.667


  12 in total

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