BACKGROUND: We undertook an observational follow-up study of schistosomiasis serology in both travelers and immigrants in a nonendemic country to determine the natural history of schistosomiasis antibody titer post-adequate treatment in those who have not been reexposed. METHODS: Longitudinal study of all adult travelers and immigrants presenting to the Royal Melbourne Hospital, Australia with positive schistosomiasis serology (titer >1: 64) between July 1995 and December 2005. All patients were treated with praziquantel and followed up clinically and serologically for a period up to 30 months. RESULTS: A total of 58 patients were included in the study including 26 travelers and 32 immigrants. Antibody titers often increased in the first 6 to 12 months post-treatment, especially in immigrants. After 30 months of post-treatment, 68% of travelers and 35% of immigrants (p < 0.01) achieved a fourfold antibody decline. CONCLUSIONS: Schistosomiasis antibody titers varied after adequate treatment. Therefore an increase in titer in the first 6 to 12 months or a failure to reduce after 3 years should not automatically justify re-treatment.
BACKGROUND: We undertook an observational follow-up study of schistosomiasis serology in both travelers and immigrants in a nonendemic country to determine the natural history of schistosomiasis antibody titer post-adequate treatment in those who have not been reexposed. METHODS: Longitudinal study of all adult travelers and immigrants presenting to the Royal Melbourne Hospital, Australia with positive schistosomiasis serology (titer >1: 64) between July 1995 and December 2005. All patients were treated with praziquantel and followed up clinically and serologically for a period up to 30 months. RESULTS: A total of 58 patients were included in the study including 26 travelers and 32 immigrants. Antibody titers often increased in the first 6 to 12 months post-treatment, especially in immigrants. After 30 months of post-treatment, 68% of travelers and 35% of immigrants (p < 0.01) achieved a fourfold antibody decline. CONCLUSIONS:Schistosomiasis antibody titers varied after adequate treatment. Therefore an increase in titer in the first 6 to 12 months or a failure to reduce after 3 years should not automatically justify re-treatment.
Authors: Francesca Tamarozzi; Tamara Ursini; Pytsje T Hoekstra; Ronaldo Silva; Cecilia Costa; Federico Gobbi; Gerardo B Monteiro; Leonardo Motta; Govert J van Dam; Paul L Corstjens; Lisette van Lieshout; Dora Buonfrate Journal: Parasit Vectors Date: 2021-03-09 Impact factor: 3.876
Authors: Cécile Crosnier; Cornelis H Hokke; Anna V Protasio; Cordelia Brandt; Gabriel Rinaldi; Marijke C C Langenberg; Simon Clare; Jacqueline J Janse; Shona Wilson; Matthew Berriman; Meta Roestenberg; Gavin J Wright Journal: J Infect Dis Date: 2022-04-19 Impact factor: 7.759