AIMS: The aim of the study was to explore the validity of registry-based diagnoses of autism in Finland using the Autism Diagnostic Interview - Revised (ADI-R). This study was designed for the Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A), an ongoing research project where registry-based diagnoses will be used for epidemiological studies. METHODS: In this small pilot study, a clinical sample of 95 subjects diagnosed with childhood autism or pervasive developmental disorder/pervasive developmental disorder - not otherwise specified (PDD/PDD-NOS) or Asperger's syndrome according to the Finnish Hospital Discharge Register (FHDR) was gathered nationwide. A small control group consisting of siblings without any registered diagnoses of those being examined was also included in the study. Diagnoses were further re-evaluated by interviewing parents with the ADI-R. RESULTS: The mean scores of autistic subjects clearly exceeded cut-off limits for autism on all three ADI-R domains and 96% of the subjects with registered diagnosis of childhood autism fulfilled the criteria based on the instrument as well. CONCLUSION: These results suggest that the validity of Finnish registry-based diagnoses of childhood autism can be considered good. Our findings lay important groundwork for further population- based studies of the aetiology of autism.
AIMS: The aim of the study was to explore the validity of registry-based diagnoses of autism in Finland using the Autism Diagnostic Interview - Revised (ADI-R). This study was designed for the Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A), an ongoing research project where registry-based diagnoses will be used for epidemiological studies. METHODS: In this small pilot study, a clinical sample of 95 subjects diagnosed with childhood autism or pervasive developmental disorder/pervasive developmental disorder - not otherwise specified (PDD/PDD-NOS) or Asperger's syndrome according to the Finnish Hospital Discharge Register (FHDR) was gathered nationwide. A small control group consisting of siblings without any registered diagnoses of those being examined was also included in the study. Diagnoses were further re-evaluated by interviewing parents with the ADI-R. RESULTS: The mean scores of autistic subjects clearly exceeded cut-off limits for autism on all three ADI-R domains and 96% of the subjects with registered diagnosis of childhood autism fulfilled the criteria based on the instrument as well. CONCLUSION: These results suggest that the validity of Finnish registry-based diagnoses of childhood autism can be considered good. Our findings lay important groundwork for further population- based studies of the aetiology of autism.
Authors: Katja M Lampi; Liisa Lehtonen; Phuong Lien Tran; Auli Suominen; Venla Lehti; P Nina Banerjee; Mika Gissler; Alan S Brown; Andre Sourander Journal: J Pediatr Date: 2012-06-05 Impact factor: 4.406
Authors: Laura Timonen-Soivio; Raija Vanhala; Heli Malm; Susanna Hinkka-Yli-Salomäki; Mika Gissler; Alan Brown; Andre Sourander Journal: J Autism Dev Disord Date: 2016-08
Authors: Laura Timonen-Soivio; Andre Sourander; Heli Malm; Susanna Hinkka-Yli-Salomäki; Mika Gissler; Alan Brown; Raija Vanhala Journal: J Autism Dev Disord Date: 2015-10
Authors: Elina Jokiranta; Andre Sourander; Auli Suominen; Laura Timonen-Soivio; Alan S Brown; Matti Sillanpää Journal: J Autism Dev Disord Date: 2014-10
Authors: Katja M Lampi; Susanna Hinkka-Yli-Salomäki; Venla Lehti; Hans Helenius; Mika Gissler; Alan S Brown; Andre Sourander Journal: J Autism Dev Disord Date: 2013-11
Authors: Keely Cheslack-Postava; Panu V Rantakokko; Susanna Hinkka-Yli-Salomäki; Heljä-Marja Surcel; Ian W McKeague; Hannu A Kiviranta; Andre Sourander; Alan S Brown Journal: Neurotoxicol Teratol Date: 2013-04-13 Impact factor: 3.763