Literature DB >> 20411779

Age and Parkinson's disease-related neuronal death in the substantia nigra pars compacta.

Nina Eriksen1, Anette Kirstine Stark, Bente Pakkenberg.   

Abstract

During aging, decline in memory and cognitive abilities as well as motor weakening is of great concern. The dopaminergic system mediates some aspects of manual dexterity, in addition to cognition and emotion, and may be especially vulnerable to aging. A common neurodegenerative disorder of this system, Parkinson's disease, is characterized by a selective, progressive loss of dopaminergic neurons in the substantia nigra pars compacta. This review includes studies quantifying age and Parkinson's-related changes of the substantia nigra, with emphasis on stereological studies performed in the substantia nigra pars compacta.

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Year:  2009        PMID： 20411779     DOI： 10.1007/978-3-211-92660-4_16

Source DB:  PubMed          Journal:  J Neural Transm Suppl        ISSN： 0303-6995


  12 in total

1.  Role of ERK1, 2, and 5 in dopamine neuron survival during aging.

Authors:  Mayur S Parmar; Juliann D Jaumotte; Stephanie L Wyrostek; Michael J Zigmond; Jane E Cavanaugh
Journal:  Neurobiol Aging       Date:  2013-10-23       Impact factor: 4.673

2.  L-DOPA reverses motor deficits associated with normal aging in mice.

Authors:  Erika Allen; Kirsten M Carlson; Michael J Zigmond; Jane E Cavanaugh
Journal:  Neurosci Lett       Date:  2010-11-25       Impact factor: 3.046

3.  Altered nucleolar morphology in substantia nigra dopamine neurons following 6-hydroxydopamine lesion in rats.

Authors:  Michelle Healy-Stoffel; S Omar Ahmad; John A Stanford; Beth Levant
Journal:  Neurosci Lett       Date:  2013-05-02       Impact factor: 3.046

4.  A novel use of combined tyrosine hydroxylase and silver nucleolar staining to determine the effects of a unilateral intrastriatal 6-hydroxydopamine lesion in the substantia nigra: a stereological study.

Authors:  Michelle Healy-Stoffel; S Omar Ahmad; John A Stanford; Beth Levant
Journal:  J Neurosci Methods       Date:  2012-07-28       Impact factor: 2.390

Review 5.  Cognitive Impairment Associated with Parkinson's Disease: Role of Mitochondria.

Authors:  Nihar R Das; Shyam S Sharma
Journal:  Curr Neuropharmacol       Date:  2016       Impact factor: 7.363

6.  Application of the Physical Disector Principle for Quantification of Dopaminergic Neuronal Loss in a Rat 6-Hydroxydopamine Nigral Lesion Model of Parkinson's Disease.

Authors:  Katrine Fabricius; Pernille Barkholt; Jacob Jelsing; Henrik H Hansen
Journal:  Front Neuroanat       Date:  2017-12-08       Impact factor: 3.856

Review 7.  Dopamine compartmentalization, selective dopaminergic vulnerabilities in Parkinson's disease and therapeutic opportunities.

Authors:  George R Uhl
Journal:  Ann Clin Transl Neurol       Date:  2019-01-08       Impact factor: 4.511

Review 8.  The human olfactory system in two proteinopathies: Alzheimer's and Parkinson's diseases.

Authors:  Isabel Ubeda-Bañon; Daniel Saiz-Sanchez; Alicia Flores-Cuadrado; Ernesto Rioja-Corroto; Melania Gonzalez-Rodriguez; Sandra Villar-Conde; Veronica Astillero-Lopez; Juan Pablo Cabello-de la Rosa; Maria Jose Gallardo-Alcañiz; Julia Vaamonde-Gamo; Fernanda Relea-Calatayud; Lucia Gonzalez-Lopez; Alicia Mohedano-Moriano; Alberto Rabano; Alino Martinez-Marcos
Journal:  Transl Neurodegener       Date:  2020-06-03       Impact factor: 8.014

9.  Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease.

Authors:  Urmas Roostalu; Casper B G Salinas; Ditte D Thorbek; Jacob L Skytte; Katrine Fabricius; Pernille Barkholt; Linu M John; Vanessa Isabell Jurtz; Lotte Bjerre Knudsen; Jacob Jelsing; Niels Vrang; Henrik H Hansen; Jacob Hecksher-Sørensen
Journal:  Dis Model Mech       Date:  2019-11-22       Impact factor: 5.758

10.  Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson's Disease.

Authors:  Gian-Carlo Eyer; Stefano Di Santo; Ekkehard Hewer; Lukas Andereggen; Stefanie Seiler; Hans Rudolf Widmer
Journal:  Cells       Date:  2021-11-30       Impact factor: 6.600
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