Literature DB >> 20411698

Obstructive sleep apnea presenting as pseudopheochromocytoma.

Michael K Cheezum1, Christopher J Lettieri.   

Abstract

A 39-year-old man with a history of poorly controlled hypertension presented with a 2-year history of fatigue, daytime somnolence, and intermittent episodes of diaphoresis and palpitations. Episodes were self-limiting, lasting approximately 5-10 minutes and occurred several times per month, most notably at night. Laboratory evaluation was significant for elevated 24-h urinary catecholamine levels, suggestive of pheochromocytoma. However, thorough imaging failed to identify a catecholamine-secreting tumor. Subsequent polysomnography revealed severe obstructive sleep apnea, with an apnea-hypopnea index of 112 events/h. After one month of continuous positive airway pressure therapy, the patient experienced resolution of his presenting symptoms, improved blood pressure control and normalization of his urinary catecholamine levels. This case highlights sleep disordered breathing as a potentially reversible cause of pseudopheochromocytoma.

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Year:  2010        PMID: 20411698      PMCID: PMC2854708     

Source DB:  PubMed          Journal:  J Clin Sleep Med        ISSN: 1550-9389            Impact factor:   4.062


  6 in total

1.  Acute effects of nasal continuous positive airway pressure on 24-hour blood pressure and catecholamines in patients with obstructive sleep apnea.

Authors:  H Minemura; T Akashiba; H Yamamoto; T Akahoshi; N Kosaka; T Horie
Journal:  Intern Med       Date:  1998-12       Impact factor: 1.271

2.  Pseudopheochromocytoma.

Authors:  O Kuchel
Journal:  Hypertension       Date:  1985 Jan-Feb       Impact factor: 10.190

3.  Reduced cardiac sympathetic autonomic tone after long-term nasal continuous positive airway pressure in obstructive sleep apnoea syndrome.

Authors:  F Roche; I Court-Fortune; V Pichot; D Duverney; F Costes; A Emonot; J M Vergnon; A Geyssant; J R Lacour; J C Barthélémy
Journal:  Clin Physiol       Date:  1999-03

4.  A case of sleep apnea syndrome manifesting severe hypertension with high plasma norepinephrine levels.

Authors:  Shinya Makino; Masanobu Iwata; Masayoshi Fujiwara; Shinpei Ike; Hitone Tateyama
Journal:  Endocr J       Date:  2006-05-23       Impact factor: 2.349

5.  Unexplained symptomatic paroxysmal hypertension in pseudopheochromocytoma: a stress response disorder?

Authors:  Graeme Eisenhofer; Yehonatan Sharabi; Karel Pacak
Journal:  Ann N Y Acad Sci       Date:  2008-12       Impact factor: 5.691

6.  Obstructive sleep apnea presenting as pseudopheochromocytoma: a case report.

Authors:  L J Hoy; M Emery; J A Wedzicha; A G Davison; S L Chew; J P Monson; K A Metcalfe
Journal:  J Clin Endocrinol Metab       Date:  2004-05       Impact factor: 5.958

  6 in total
  5 in total

1.  Sympathetic and catecholaminergic alterations in sleep apnea with particular emphasis on children.

Authors:  Fahed Hakim; David Gozal; Leila Kheirandish-Gozal
Journal:  Front Neurol       Date:  2012-01-30       Impact factor: 4.003

2.  Lateralizing sensorimotor deficits in a case of pseudopheochromocytoma.

Authors:  Joome Suh; Courtney Quinn; Alia Rehwinkel
Journal:  Yale J Biol Med       Date:  2014-12-12

3.  Pseudopheochromocytoma Associated with Domestic Assault.

Authors:  H M Le; G Carbutti; D Ilisei; E Bouccin; X Vandemergel
Journal:  Case Rep Cardiol       Date:  2016-09-21

4.  The Importance of Exclusion of Obstructive Sleep Apnea During Screening for Adrenal Adenoma and Diagnosis of Pheochromocytoma.

Authors:  Alicia C Weeks; Michelle E Kimple; Dawn Belt Davis
Journal:  J Investig Med High Impact Case Rep       Date:  2015-09-19

Review 5.  Continuous positive airway pressure therapy reduces the levels of catecholamines and blood pressure in pseudophaeochromocytoma with coexisting obstructive sleep apnoea.

Authors:  Gie Ken-Dror; Michael Wood; David Fluck; Pankaj Sharma; Christopher H Fry; Thang S Han
Journal:  JRSM Cardiovasc Dis       Date:  2021-03-17
  5 in total

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