Literature DB >> 204111

Cholesterol metabolism in man.

S M Grundy.   

Abstract

Recent investigations on cholesterol metabolism in man have led to new insights into diseases associated with abnormal accumulations of cholesterol in plasma (hypercholesterolemia), arterial tissues (atherosclerosis) and biliary tract (gallstones). Regulation of cholesterol synthesis under the influence of dietary and plasma cholesterol, may play a crucial role in determining biliary and tissue concentrations of this sterol. Plasma concentrations, on the other hand, appear to be controlled by complex mechanisms for secretion, transformation and removal of plasma lipoproteins. The recent identification of specific cellular receptors for uptake of plasma lipoproteins represents a significant advance for the understanding of regulation of both plasma and tissue concentrations, and possibly of the basic mechanisms underlying accumulation of cholesterol in atherosclerotic plaques.

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Year:  1978        PMID： 204111      PMCID： PMC1237959     

Source DB:  PubMed          Journal:  West J Med        ISSN： 0093-0415


  108 in total

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Authors:  M D SIPERSTEIN; I L CHAIKOFF; W O REINHARDT
Journal:  J Biol Chem       Date:  1952-09       Impact factor: 5.157

2.  Regulation of cholesterol biosynthesis in rat liver: diurnal changes of activity and influence of bile acids.

Authors:  P Back; B Hamprecht; F Lynen
Journal:  Arch Biochem Biophys       Date:  1969-08       Impact factor: 4.013

3.  Sterol and bile acid excretion in man and the effects of dietary fat.

Authors:  J Avigan; D Steinberg
Journal:  J Clin Invest       Date:  1965-11       Impact factor: 14.808

4.  A multivariate analysis of the risk of coronary heart disease in Framingham.

Authors:  J Truett; J Cornfield; W Kannel
Journal:  J Chronic Dis       Date:  1967-07

5.  Effect of biliary drainage on individual reactions in the conversion of cholesterol to taurochlic acid. Bile acids and steroids 180.

Authors:  H Danielsson; K Einarsson; G Johansson
Journal:  Eur J Biochem       Date:  1967-07

6.  Cholesterol synthesis by liver. III. Its regulation by ingested cholesterol.

Authors:  G M TOMKINS; H SHEPPARD; I L CHAIKOFF
Journal:  J Biol Chem       Date:  1953-03       Impact factor: 5.157

7.  Turnover of plasma esterified cholesterol in normocholesterolemic and hypercholesterolemic subjects and its relation to body build.

Authors:  P J Nestel; E A Monger
Journal:  J Clin Invest       Date:  1967-06       Impact factor: 14.808

8.  Absorption of cholesterol from a micellar solution: intestinal perfusion studies in man.

Authors:  W J Simmonds; A F Hofmann; E Theodor
Journal:  J Clin Invest       Date:  1967-05       Impact factor: 14.808

9.  The interaction of cholesterol absorption and cholesterol synthesis in man.

Authors:  S M Grundy; E H Ahrens; J Davignon
Journal:  J Lipid Res       Date:  1969-05       Impact factor: 5.922

10.  Cholesterol metabolism. I. Effect of dietary cholesterol on the synthesis of cholesterol in dog tissue in vitro.

Authors:  R G GOULD; C B TAYLOR; J S HAGERMAN; I WARNER; D J CAMPBELL
Journal:  J Biol Chem       Date:  1953-04       Impact factor: 5.157
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  10 in total

1.  Computational model for monitoring cholesterol metabolism.

Authors:  R Selvakumar; M Rashith Muhammad; G Poornima Devi
Journal:  Syst Synth Biol       Date:  2014-08-01

Review 2.  HMG-CoA reductase inhibitors and myotoxicity.

Authors:  M Ucar; T Mjörndal; R Dahlqvist
Journal:  Drug Saf       Date:  2000-06       Impact factor: 5.606

Review 3.  Statin therapy: does sex matter?

Authors:  Stephanie S Faubion; Ekta Kapoor; Ann M Moyer; Howard N Hodis; Virginia M Miller
Journal:  Menopause       Date:  2019-12       Impact factor: 2.953

4.  Bile acid sequestrants: mechanisms of action on bile acid and cholesterol metabolism.

Authors:  K Einarsson; S Ericsson; S Ewerth; E Reihnér; M Rudling; D Ståhlberg; B Angelin
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

Review 5.  Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia.

Authors:  D McTavish; E M Sorkin
Journal:  Drugs       Date:  1991-07       Impact factor: 9.546

6.  [Relation between serum lipoprotein metabolism and biliary lipid metabolism].

Authors:  O Leiss; K von Bergmann
Journal:  Klin Wochenschr       Date:  1983-06-15

7.  Hepatic uptake of bile acids in man. Fasting and postprandial concentrations of individual bile acids in portal venous and systemic blood serum.

Authors:  B Angelin; I Björkhem; K Einarsson; S Ewerth
Journal:  J Clin Invest       Date:  1982-10       Impact factor: 14.808

8.  Liposomal cholesterol delivery activates the macrophage innate immune arm to facilitate intracellular Leishmania donovani killing.

Authors:  June Ghosh; Rajan Guha; Shantanabha Das; Syamal Roy
Journal:  Infect Immun       Date:  2013-11-25       Impact factor: 3.441

9.  Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

Authors:  A W Alberts; J Chen; G Kuron; V Hunt; J Huff; C Hoffman; J Rothrock; M Lopez; H Joshua; E Harris; A Patchett; R Monaghan; S Currie; E Stapley; G Albers-Schonberg; O Hensens; J Hirshfield; K Hoogsteen; J Liesch; J Springer
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

10.  Camphene, a plant-derived monoterpene, reduces plasma cholesterol and triglycerides in hyperlipidemic rats independently of HMG-CoA reductase activity.

Authors:  Ioanna Vallianou; Nikolaos Peroulis; Panayotis Pantazis; Margarita Hadzopoulou-Cladaras
Journal:  PLoS One       Date:  2011-11-03       Impact factor: 3.240
  10 in total

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