BACKGROUND: Alterations in plasma fatty acid distribution are linked to metabolic abnormalities related to type 2 diabetes and cardiovascular disease. OBJECTIVE: The aim of this study was to investigate genetic factors influencing plasma fatty acid distribution in Alaskan Eskimos from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. DESIGN: Fatty acids in plasma were measured by gas chromatography in 761 related individuals (>35 y of age). RESULTS: Quantitative genetic analyses showed that fatty acid distribution is significantly heritable (P < 0.001), with heritabilities ranging from 0.33 to 0.55. A genome-wide scan for plasma fatty acids identified a 20-cM region on chromosome 8 (p12-p21) with a quantitative trait locus for monounsaturated fatty acids (logarithm of odds score = 3.8). The same region had a quantitative trait locus for polyunsaturated fatty acids (logarithm of odds score = 2.6). We genotyped single nucleotide polymorphisms (SNPs) in candidate genes in 8p12-p21 and found a significant association between fatty acids and SNPs in apolipoprotein J (APOJ), lipoprotein lipase (LPL), macrophage scavenger receptor 1 (MSR1), and tumor necrosis factor receptor superfamily member 10b (TNFRSF10B). A Bayesian quantitative trait nucleotide analysis based on a measured genotype model showed that SNPs in LPL, TNFRSF10B, and APOJ had strong statistical evidence of a functional effect (posterior probability > or =75%) on plasma fatty acid distribution. CONCLUSIONS: The results indicate that there is strong genetic influence on plasma fatty acid distribution and that genetic variation in APOJ, LPL, and TNFRSF10B may play a role. The GOCADAN study was registered at www.clinicaltrials.gov as NCT00006192.
BACKGROUND: Alterations in plasma fatty acid distribution are linked to metabolic abnormalities related to type 2 diabetes and cardiovascular disease. OBJECTIVE: The aim of this study was to investigate genetic factors influencing plasma fatty acid distribution in Alaskan Eskimos from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. DESIGN:Fatty acids in plasma were measured by gas chromatography in 761 related individuals (>35 y of age). RESULTS: Quantitative genetic analyses showed that fatty acid distribution is significantly heritable (P < 0.001), with heritabilities ranging from 0.33 to 0.55. A genome-wide scan for plasma fatty acids identified a 20-cM region on chromosome 8 (p12-p21) with a quantitative trait locus for monounsaturated fatty acids (logarithm of odds score = 3.8). The same region had a quantitative trait locus for polyunsaturated fatty acids (logarithm of odds score = 2.6). We genotyped single nucleotide polymorphisms (SNPs) in candidate genes in 8p12-p21 and found a significant association between fatty acids and SNPs in apolipoprotein J (APOJ), lipoprotein lipase (LPL), macrophage scavenger receptor 1 (MSR1), and tumor necrosis factor receptor superfamily member 10b (TNFRSF10B). A Bayesian quantitative trait nucleotide analysis based on a measured genotype model showed that SNPs in LPL, TNFRSF10B, and APOJ had strong statistical evidence of a functional effect (posterior probability > or =75%) on plasma fatty acid distribution. CONCLUSIONS: The results indicate that there is strong genetic influence on plasma fatty acid distribution and that genetic variation in APOJ, LPL, and TNFRSF10B may play a role. The GOCADAN study was registered at www.clinicaltrials.gov as NCT00006192.
Authors: Gurdeep S Sagoo; Iain Tatt; Georgia Salanti; Adam S Butterworth; Nadeem Sarwar; Merel van Maarle; J Wouter Jukema; Björn Wiman; John J P Kastelein; Anna M Bennet; Ulf de Faire; John Danesh; Julian P T Higgins Journal: Am J Epidemiol Date: 2008-10-15 Impact factor: 4.897
Authors: Cristen J Willer; Serena Sanna; Anne U Jackson; Angelo Scuteri; Lori L Bonnycastle; Robert Clarke; Simon C Heath; Nicholas J Timpson; Samer S Najjar; Heather M Stringham; James Strait; William L Duren; Andrea Maschio; Fabio Busonero; Antonella Mulas; Giuseppe Albai; Amy J Swift; Mario A Morken; Narisu Narisu; Derrick Bennett; Sarah Parish; Haiqing Shen; Pilar Galan; Pierre Meneton; Serge Hercberg; Diana Zelenika; Wei-Min Chen; Yun Li; Laura J Scott; Paul A Scheet; Jouko Sundvall; Richard M Watanabe; Ramaiah Nagaraja; Shah Ebrahim; Debbie A Lawlor; Yoav Ben-Shlomo; George Davey-Smith; Alan R Shuldiner; Rory Collins; Richard N Bergman; Manuela Uda; Jaakko Tuomilehto; Antonio Cao; Francis S Collins; Edward Lakatta; G Mark Lathrop; Michael Boehnke; David Schlessinger; Karen L Mohlke; Gonçalo R Abecasis Journal: Nat Genet Date: 2008-01-13 Impact factor: 38.330
Authors: V Saroja Voruganti; Sandra Laston; Karin Haack; Nitesh R Mehta; Shelley A Cole; Nancy F Butte; Anthony G Comuzzie Journal: Am J Clin Nutr Date: 2015-01-28 Impact factor: 7.045
Authors: B T Steffen; L M Steffen; R Tracy; D Siscovick; D Jacobs; K Liu; K He; N Q Hanson; J A Nettleton; M Y Tsai Journal: Eur J Clin Nutr Date: 2012-01-04 Impact factor: 4.016
Authors: Robert Drummond; David M Cauvi; Dennis Hawisher; Donghuan Song; Diego F Niño; Raul Coimbra; Stephen Bickler; Antonio De Maio Journal: Innate Immun Date: 2012-07-02 Impact factor: 2.680
Authors: V Saroja Voruganti; Nora Franceschini; Karin Haack; Sandra Laston; Jean W MacCluer; Jason G Umans; Anthony G Comuzzie; Kari E North; Shelley A Cole Journal: Eur J Hum Genet Date: 2013-12-04 Impact factor: 4.246
Authors: Matthew O Gribble; Venkata Saroja Voruganti; Cheryl D Cropp; Kevin A Francesconi; Walter Goessler; Jason G Umans; Ellen K Silbergeld; Sandra L Laston; Karin Haack; Wen Hong Linda Kao; Margaret Daniele Fallin; Jean W Maccluer; Shelley A Cole; Ana Navas-Acien Journal: Toxicol Sci Date: 2013-08-22 Impact factor: 4.849
Authors: V Saroja Voruganti; Paul B Higgins; Sven O E Ebbesson; John Kennish; Harald H H Göring; Karin Haack; Sandra Laston; Eugene Drigalenko; Charlotte R Wenger; William S Harris; Richard R Fabsitz; Richard B Devereux; Jean W Maccluer; Joanne E Curran; Melanie A Carless; Matthew P Johnson; Eric K Moses; John Blangero; Jason G Umans; Barbara V Howard; Shelley A Cole; Anthony Gean Comuzzie Journal: Front Genet Date: 2012-06-11 Impact factor: 4.599
Authors: Victor M Hernandez-Escalante; Edna J Nava-Gonzalez; V Saroja Voruganti; Jack W Kent; Karin Haack; Hugo A Laviada-Molina; Fernanda Molina-Segui; Esther C Gallegos-Cabriales; Juan Carlos Lopez-Alvarenga; Shelley A Cole; Marguerite J Mezzles; Anthony G Comuzzie; Raul A Bastarrachea Journal: Front Genet Date: 2014-11-18 Impact factor: 4.599