Literature DB >> 20409595

Challenges in reducing the burden of otitis media disease: an ENT perspective on improving management and prospects for prevention.

Gerhard Grevers1.   

Abstract

Acute otitis media (AOM) is a major public health concern. This frequent disease of childhood is a leading cause of physician visits, a major component of paediatric healthcare burden, and a key contributor to antibiotic resistance. An international expert group comprising mainly ear, nose, and throat physicians met in June 2008 to discuss the optimal management of AOM, particularly with regards to unmet needs in diagnosis and management. Current guidelines do not help identify which patients are most at risk for severe or complicated AOM. Diagnosis of AOM is also complicated by a lack of correlation between clinical signs and symptoms and responsible pathogens. Consequently, treatment of AOM is not always appropriate, and the long-term overuse of antibiotics in AOM reduces the effectiveness of treatment and places children at risk for drug-resistant infections. There is a need for educational and research initiatives to improve diagnostic accuracy and management of AOM. Because there is currently no ideal treatment, vaccination is an attractive additional approach for managing AOM and reducing its burden. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.

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Year:  2010        PMID: 20409595     DOI: 10.1016/j.ijporl.2010.03.049

Source DB:  PubMed          Journal:  Int J Pediatr Otorhinolaryngol        ISSN: 0165-5876            Impact factor:   1.675


  23 in total

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Authors:  Suzanne J C Verhaegh; Kim Stol; Corné P de Vogel; Kristian Riesbeck; Eric R Lafontaine; Timothy F Murphy; Alex van Belkum; Peter W M Hermans; John P Hays
Journal:  Clin Vaccine Immunol       Date:  2012-04-25

2.  Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response.

Authors:  S Joo; Y Fukuyama; E J Park; Y Yuki; Y Kurashima; R Ouchida; S F Ziegler; H Kiyono
Journal:  Mucosal Immunol       Date:  2016-12-07       Impact factor: 7.313

3.  Interspecies bacterial communication as a target for therapy in otitis media.

Authors:  Chelsie E Armbruster; W Edward Swords
Journal:  Expert Rev Anti Infect Ther       Date:  2010-10       Impact factor: 5.091

4.  Acute otitis media in children 6 months to 2 years of age.

Authors:  Ran D Goldman
Journal:  Can Fam Physician       Date:  2022-08       Impact factor: 3.025

5.  Streptococcus salivarius 24SMB administered by nasal spray for the prevention of acute otitis media in otitis-prone children.

Authors:  P Marchisio; M Santagati; M Scillato; E Baggi; M Fattizzo; C Rosazza; S Stefani; S Esposito; N Principi
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2015-09-18       Impact factor: 3.267

6.  Pneumococcal PspA and PspC proteins: potential vaccine candidates for experimental otitis media.

Authors:  Patricia A Schachern; Vladimir Tsuprun; Patricia Ferrieri; David E Briles; Sarah Goetz; Sebahattin Cureoglu; Michael M Paparella; Steven Juhn
Journal:  Int J Pediatr Otorhinolaryngol       Date:  2014-06-24       Impact factor: 1.675

7.  A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2.

Authors:  E Kaitlynn Allen; Wei-Min Chen; Daniel E Weeks; Fang Chen; Xuanlin Hou; José L Mattos; Josyf C Mychaleckyj; Fernando Segade; Margaretha L Casselbrant; Ellen M Mandel; Robert E Ferrell; Stephen S Rich; Kathleen A Daly; Michèle M Sale
Journal:  J Assoc Res Otolaryngol       Date:  2013-08-23

8.  Significant linkage at chromosome 19q for otitis media with effusion and/or recurrent otitis media (COME/ROM).

Authors:  Wei-Min Chen; E Kaitlynn Allen; Josyf C Mychaleckyj; Fang Chen; Xuanlin Hou; Stephen S Rich; Kathleen A Daly; Michèle M Sale
Journal:  BMC Med Genet       Date:  2011-09-26       Impact factor: 2.103

9.  C-Terminal Clostridium perfringens Enterotoxin-Mediated Antigen Delivery for Nasal Pneumococcal Vaccine.

Authors:  Hidehiko Suzuki; Akihiro Watari; Eri Hashimoto; Miki Yonemitsu; Hiroshi Kiyono; Kiyohito Yagi; Masuo Kondoh; Jun Kunisawa
Journal:  PLoS One       Date:  2015-05-27       Impact factor: 3.240

10.  The Impact of Childhood Acute Otitis Media on Parental Quality of Life in a Prospective Observational Cohort Study.

Authors:  Katsiaryna Holl; Mats Rosenlund; Carlo Giaquinto; Sven-Arne Silfverdal; Alfonso Carmona; James Larcombe; José Garcia-Sicilia; Ahmet Fuat; Maria Eulalia Muñoz; María Luisa Arroba; Brigitte Sloesen; Jens Vollmar; Jean-Yves Pirçon; Johannes G Liese
Journal:  Clin Drug Investig       Date:  2015-10       Impact factor: 2.859

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