Literature DB >> 20408238

In vivo measurement of blood oxygen saturation using magnetic resonance imaging: a direct validation of the blood oxygen level-dependent concept in functional brain imaging.

E M Haacke1, S Lai, J R Reichenbach, K Kuppusamy, F G Hoogenraad, H Takeichi, W Lin.   

Abstract

A novel noninvasive magnetic resonance imaging (MRI) method was developed to determine in vivo blood oxygen saturation and its changes during motor cortex activation in small cerebral veins. Specifically, based on susceptibility measurements in the resting states, pial veins were found to have a mean oxygen saturation of Yrest=0.544+/-0.029 averaged over 14 vessels in 5 volunteers. During activation, susceptibility measurements revealed an oxygen saturation change of DeltaYsusc=0.14+/-0.02. Independent evaluation from blood flow velocity measurements yielded a value of DeltaYflow=0.14+/-0.04 for this change. These results validate the blood oxygenation level-dependent (BOLD) model in functional MRI (fMRI). Copyright (c) 1997 Wiley-Liss, Inc.

Entities:  

Year:  1997        PMID： 20408238     DOI： 10.1002/(SICI)1097-0193(1997)5:5<341::AID-HBM2>3.0.CO;2-3

Source DB:  PubMed          Journal:  Hum Brain Mapp        ISSN： 1065-9471            Impact factor:   5.038


  92 in total

1.  Improving high-resolution MR bold venographic imaging using a T1 reducing contrast agent.

Authors:  W Lin; P Mukherjee; H An; Y Yu; Y Wang; K Vo; B Lee; D Kido; E M Haacke
Journal:  J Magn Reson Imaging       Date:  1999-08       Impact factor: 4.813

2.  New insights into the hemodynamic blood oxygenation level-dependent response through combination of functional magnetic resonance imaging and optical recording in gerbil barrel cortex.

Authors:  A Hess; D Stiller; T Kaulisch; P Heil; H Scheich
Journal:  J Neurosci       Date:  2000-05-01       Impact factor: 6.167

3.  Investigating the magnetic susceptibility properties of fresh human blood for noninvasive oxygen saturation quantification.

Authors:  Varsha Jain; Osheiza Abdulmalik; Kathleen Joy Propert; Felix W Wehrli
Journal:  Magn Reson Med       Date:  2011-12-08       Impact factor: 4.668

4.  Venous oxygenation mapping using velocity-selective excitation and arterial nulling.

Authors:  Jia Guo; Eric C Wong
Journal:  Magn Reson Med       Date:  2012-01-31       Impact factor: 4.668

5.  MRI estimation of global brain oxygen consumption rate.

Authors:  Varsha Jain; Michael C Langham; Felix W Wehrli
Journal:  J Cereb Blood Flow Metab       Date:  2010-04-21       Impact factor: 6.200

6.  Susceptibility weighted imaging in cerebral hypoperfusion-can we predict increased oxygen extraction fraction?

Authors:  Chandrasekharan Kesavadas; Kannath Santhosh; Bejoy Thomas
Journal:  Neuroradiology       Date:  2010-06-22       Impact factor: 2.804

7.  The impact of restricted diet on brain function using BOLD-fMRI.

Authors:  Saïd Boujraf; N Benajiba; F Belahsen; S Tizniti; L J Garey
Journal:  Exp Brain Res       Date:  2006-05-19       Impact factor: 1.972

8.  In vivo whole-blood T2 versus HbO2 calibration by modulating blood oxygenation level in the femoral vein through intermittent cuff occlusion.

Authors:  Michael C Langham; Ana E Rodríguez-Soto; Nadav Schwartz; Felix W Wehrli
Journal:  Magn Reson Med       Date:  2017-09-03       Impact factor: 4.668

Review 9.  Time-resolved MRI oximetry for quantifying CMRO(2) and vascular reactivity.

Authors:  Felix W Wehrli; Zachary B Rodgers; Varsha Jain; Michael C Langham; Cheng Li; Daniel J Licht; Jeremy Magland
Journal:  Acad Radiol       Date:  2014-02       Impact factor: 3.173

10.  Quantitative evaluation of oxygenation in venous vessels using T2-Relaxation-Under-Spin-Tagging MRI.

Authors:  Hanzhang Lu; Yulin Ge
Journal:  Magn Reson Med       Date:  2008-08       Impact factor: 4.668
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