| Literature DB >> 20407674 |
Laurence Carroll1, Romain Bejot, Rebekka Hueting, Robert King, Paul Bonnitcha, Simon Bayly, Martin Christlieb, Jonathan R Dilworth, Antony D Gee, Jérôme Declerck, Véronique Gouverneur.
Abstract
The synthesis of three pairs of orthogonally labelled fluorinated Cu bis(thiosemicarbazonato) complexes is presented. These are the first examples of (18)F-labelled Cu(II)-complexes designed to serve as new hypoxia selective PET tracers and as mechanistic probes to study the mode of action of this class of markers. In vitro evaluation revealed that the fluorinated Cu-complex derived from amide coupling is suitable for in vivo work.Entities:
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Year: 2010 PMID： 20407674 DOI： 10.1039/b926980k
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222