Literature DB >> 204066

Somatic cell hybrids between Friend erythroleukemia cells and mouse hepatoma cells.

J F Conscience, F H Ruddle, A Skoultchi, G J Darlington.   

Abstract

Somatic cell hybrids between hepatoma and Friend erythroleukemia parental cells were studied for the expression of liver-specific and erythroid properties. Several independent clones were isolated using HAT selection and were shown to be true hybrids by isozyme and chromosome analysis. All displayed a complete extinction of hemoglobin and globin mRNA production, but a retention of albumin and transferrin secretion. The data suggest that erythroid differntiation is being actively inhibited by the hepatoma genome. Possible mechanisms that might explain these results are discussed in the light of current hypotheses regarding the mechanism of cell differentiation.

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Year:  1977        PMID： 204066     DOI： 10.1007/bf01551812

Source DB:  PubMed          Journal:  Somatic Cell Genet        ISSN： 0098-0366


  9 in total

1.  Trans acting regulation of beta globin gene expression in erythroleukemia (K562) cells.

Authors:  K Young; M Donovan-Peluso; R Cubbon; A Bank
Journal:  Nucleic Acids Res       Date:  1985-07-25       Impact factor: 16.971

2.  Activation and repression of a beta-globin gene in cell hybrids is accompanied by a shift in its temporal replication.

Authors:  V Dhar; A I Skoultchi; C L Schildkraut
Journal:  Mol Cell Biol       Date:  1989-08       Impact factor: 4.272

3.  Introduction and expression of a fetal human globin gene in mouse fibroblasts.

Authors:  N Hsiung; R S Roginski; P Henthorn; O Smithies; R Kucherlapati; A I Skoultchi
Journal:  Mol Cell Biol       Date:  1982-04       Impact factor: 4.272

4.  Cell cycle regulation of mouse H3 histone mRNA metabolism.

Authors:  R B Alterman; S Ganguly; D H Schulze; W F Marzluff; C L Schildkraut; A I Skoultchi
Journal:  Mol Cell Biol       Date:  1984-01       Impact factor: 4.272

5.  Activation of phenotypic expression of human globin genes from nonerythroid cells by chromosome-dependent transfer to tetraploid mouse erythroleukemia cells.

Authors:  A Deisseroth; D Hendrick
Journal:  Proc Natl Acad Sci U S A       Date:  1979-05       Impact factor: 11.205

6.  Negative control of hemoglobin production in somatic cell hybrids due to heme deficiency.

Authors:  S Benoff; S A Bruce; A I Skoultchi
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

7.  Activation of human beta-globin genes from nonerythroid cells by fusion with murine erythroleukemia cells.

Authors:  J Pyati; R S Kucherlapati; A I Skoultchi
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

8.  Inducibility of spleen focus-forming virus by BrdUrd is controlled by the differentiated state of the cell.

Authors:  I Greiser-Wilke; W Ostertag; P Goldfarb; A Lang; M Furusawa; J F Conscience
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

9.  Immunofluorescence analysis of the time-course of extinction, reexpression, and activation of albumin production in rat hepatoma-mouse fibroblast heterokaryons and hybrids.

Authors:  M Mével-Ninio; M C Weiss
Journal:  J Cell Biol       Date:  1981-08       Impact factor: 10.539
  9 in total

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