Literature DB >> 20405845

Antibiotic indole sesquiterpene alkaloid from Greenwayodendron suaveolens with a new natural product framework.

Russell B Williams1, Jin-Feng Hu, Krista M Olson, Vanessa L Norman, Matt G Goering, Mark O'Neil-Johnson, Gary R Eldridge, Courtney M Starks.   

Abstract

High-throughput natural products chemistry methods have led to the isolation of three new (1-3) and two known indole sesquiterpene alkaloids (4, 5) from Greenwayodendron suaveolens. Their structures were determined using CapNMR and MS. Pentacyclindole (1) was determined to possess a new natural product framework. Pentacyclindole (1) and polyalthenol (4) showed activity against clinical isolates of Staphylococcus aureus with polyalthenol (4) demonstrating a MIC(90) of 4 microg/mL.

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Year:  2010        PMID： 20405845     DOI： 10.1021/np1001225

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  3 in total

1.  Cytotoxic and antibacterial beilschmiedic acids from a Gabonese species of Beilschmiedia.

Authors:  Russell B Williams; Steven M Martin; Jin-Feng Hu; Vanessa L Norman; Matt G Goering; Sandra Loss; Mark O'Neil-Johnson; Gary R Eldridge; Courtney M Starks
Journal:  J Nat Prod       Date:  2012-07-03       Impact factor: 4.050

Review 2.  Indole alkaloids from marine sources as potential leads against infectious diseases.

Authors:  Paulo H B França; Daniel P Barbosa; Daniel L da Silva; Êurica A N Ribeiro; Antônio E G Santana; Bárbara V O Santos; José M Barbosa-Filho; Jullyana S S Quintans; Rosana S S Barreto; Lucindo J Quintans-Júnior; João X de Araújo-Júnior
Journal:  Biomed Res Int       Date:  2014-06-05       Impact factor: 3.411

3.  Regioselective Mercury(I)/Palladium(II)-Catalyzed Single-Step Approach for the Synthesis of Imines and 2-Substituted Indoles.

Authors:  Rsuini U Gutiérrez; Mayra Hernández-Montes; Aarón Mendieta-Moctezuma; Francisco Delgado; Joaquín Tamariz
Journal:  Molecules       Date:  2021-07-05       Impact factor: 4.411
  3 in total

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