OBJECTIVES: Multiple sclerosis (MS) is an inflammatory, autoimmune demyelinating disease of the central nervous system. Human Natural Resistance Associated Macrophage Protein 1 (NRAMP1) gene polymorphisms have been implicated in the immune mediated diseases susceptibility. This study aimed to investigate the plausible association between NRAMP1 gene and MS susceptibility. METHODS: We analyzed (GT)(n,) INT4, 3'UTR and D543N polymorphisms of NRAMP1 gene in 100 MS patients and 104 healthy subjects by using amplification refractory mutation system-polymerase chain reaction and sequence analysis. RESULTS: No significant association was found between (GT)(n,) INT4, 3'UTR and D543N polymorphisms and MS. There was also no correlation between NRAMP1 polymorphisms and MS clinical forms. CONCLUSIONS: Our findings suggest that NRAMP1 polymorphisms do not play a role in MS susceptibility and clinical finding of MS in Turkish patients.
OBJECTIVES:Multiple sclerosis (MS) is an inflammatory, autoimmune demyelinating disease of the central nervous system. HumanNatural Resistance Associated Macrophage Protein 1 (NRAMP1) gene polymorphisms have been implicated in the immune mediated diseases susceptibility. This study aimed to investigate the plausible association between NRAMP1 gene and MS susceptibility. METHODS: We analyzed (GT)(n,) INT4, 3'UTR and D543N polymorphisms of NRAMP1 gene in 100 MS patients and 104 healthy subjects by using amplification refractory mutation system-polymerase chain reaction and sequence analysis. RESULTS: No significant association was found between (GT)(n,) INT4, 3'UTR and D543N polymorphisms and MS. There was also no correlation between NRAMP1 polymorphisms and MS clinical forms. CONCLUSIONS: Our findings suggest that NRAMP1 polymorphisms do not play a role in MS susceptibility and clinical finding of MS in Turkish patients.
Authors: A D Sadovnick; H Armstrong; G P Rice; D Bulman; L Hashimoto; D W Paty; S A Hashimoto; S Warren; W Hader; T J Murray Journal: Ann Neurol Date: 1993-03 Impact factor: 10.422
Authors: O Ates; L Dalyan; B Müsellim; G Hatemi; H Türker; G Ongen; V Hamuryudan; A Topal-Sarikaya Journal: Int J Immunogenet Date: 2008-11-25 Impact factor: 1.466