Literature DB >> 2040366

Human alpha-calcitonin gene-related peptide-(8-37) as an antagonist of exogenous and endogenous calcitonin gene-related peptide.

C A Maggi1, T Chiba, S Giuliani.   

Abstract

The C-terminal fragment of the human alpha-calcitonin gene-related peptide (hCGRP), hCGRP-(8-37) competitively antagonized both the positive inotropic effect of hCGRP in the guinea-pig isolated left atria (pA2 6.89) and the smooth muscle relaxant effect of hCGRP in the rat isolated vas deferens (pA2 6.55) but left the response to isoprenaline unaffected in both preparations. In addition, hCGRP-(8-37) reduced the responses produced by activation of the 'efferent' function of capsaicin-sensitive primary afferents in both preparations thus providing pharmacological evidence for the involvement of endogenous CGRP. hCGRP-(8-37) appears a useful tool to establish the physiological role of CGRP in peripheral preparations from different species.

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Year:  1991        PMID： 2040366     DOI： 10.1016/0014-2999(91)90072-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  18 in total

1.  Receptors mediating CGRP-induced relaxation in the rat isolated thoracic aorta and porcine isolated coronary artery differentiated by h(alpha) CGRP(8-37).

Authors:  F M Wisskirchen; D W Gray; I Marshall
Journal:  Br J Pharmacol       Date:  1999-09       Impact factor: 8.739

2.  Adenosine receptors involved in the inhibitory control of non-adrenergic non-cholinergic neurotransmission in guinea-pig atria belong to the A1 subtype.

Authors:  A Rubino; S Amerini; L Mantelli; F Ledda
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-10       Impact factor: 3.000

3.  CGRP(2) receptor in the internal anal sphincter of the rat: implications for CGRP receptor classification.

Authors:  F M Wisskirchen; I Marshall
Journal:  Br J Pharmacol       Date:  2000-05       Impact factor: 8.739

4.  Multiple receptors for calcitonin gene-related peptide and amylin on guinea-pig ileum and vas deferens.

Authors:  A E Tomlinson; D R Poyner
Journal:  Br J Pharmacol       Date:  1996-03       Impact factor: 8.739

5.  Multiple mechanisms in the smooth muscle relaxant action of calcitonin gene-related peptide (CGRP) in the guinea-pig ureter.

Authors:  C A Maggi; S Giuliani; P Santicioli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-11       Impact factor: 3.000

6.  Alpha-adrenoceptor modulation of the efferent function of capsaicin-sensitive sensory neurones in guinea-pig isolated atria.

Authors:  S Amerini; A Rubino; L Mantelli; F Ledda
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

7.  Intrathecal CGRP8-37-induced bilateral increase in hindpaw withdrawal latency in rats with unilateral inflammation.

Authors:  L C Yu; P Hansson; G Brodda-Jansen; E Theodorsson; T Lundeberg
Journal:  Br J Pharmacol       Date:  1996-01       Impact factor: 8.739

8.  Endogenous prostaglandin I2 regulates the neural emergency system through release of calcitonin gene related peptide.

Authors:  K Arai; T Ohno; T Saeki; S Mizuguchi; K Kamata; I Hayashi; K Saigenji; T Murata; S Narumiya; M Majima
Journal:  Gut       Date:  2003-09       Impact factor: 23.059

9.  Involvement of multiple receptors in the biological effects of calcitonin gene-related peptide and amylin in rat and guinea-pig preparations.

Authors:  S Giuliani; S J Wimalawansa; C A Maggi
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739

10.  A calcitonin gene-related peptide (CGRP) antagonist (CGRP8-37) inhibits microvascular responses induced by CGRP and capsaicin in skin.

Authors:  S R Hughes; S D Brain
Journal:  Br J Pharmacol       Date:  1991-11       Impact factor: 8.739
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