Literature DB >> 2040337

A new immunoradiometric assay (IRMA) system for thyroglobulin measurement in the follow-up of thyroid cancer patients.

M Schlumberger1, P Fragu, P Gardet, J Lumbroso, D Violot, C Parmentier.   

Abstract

A new commercially available kit for thyroglobulin (Tg) measurement [immunoradiometric assay (IRMA) system based on monoclonal antibodies] was used in 479 patients with thyroid carcinoma. The effective working range was 1 ng/ml, and results were strongly correlated with our homemade radioimmunoassay (RIA). This IRMA method is less susceptible to interferences of auto-antibodies than our RIA. During thyroxine (T4) treatment, the Tg level was undetectable in 98% of patients after total thyroid ablation, in 91% after total thyroidectomy and in 42% after lobectomy only. In this situation, Tg was found in all patients with large metastases and in 88% of those with small metastases. Following T4 withdrawal, Tg was detectable in all patients with neoplastic disease and in 13% of those in complete remission after total thyroid ablation. In conclusion, Tg measured with this IRMA method appears to be a reliable marker of differentiated thyroid carcinoma.

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Year:  1991        PMID： 2040337     DOI： 10.1007/bf02262724

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  16 in total

1.  Critical evaluation of serum thyroglobulin (Tg) levels during thyroid hormone suppression therapy versus Tg levels after hormone withdrawal and total body scan: results in 291 patients with thyroid cancer.

Authors:  M E Girelli; B Busnardo; R Amerio; D Casara; C Betterle; M Piccolo
Journal:  Eur J Nucl Med       Date:  1986

2.  Thyroglobulin level helps to predict recurrence after lobo-isthmusectomy in patients with differentiated thyroid carcinoma.

Authors:  F de Vathaire; S Blanchon; M Schlumberger
Journal:  Lancet       Date:  1988 Jan 2-9       Impact factor: 79.321

3.  Evaluation of a solid-phase immunoradiometric assay (IRMA) for serum thyroglobulin: effect of anti-thyroglobulin autoantibody.

Authors:  S Mariotti; C Cupini; C Giani; R Lari; E Rolleri; A Falco; M Marchisio; A Pinchera
Journal:  Clin Chim Acta       Date:  1982-08-18       Impact factor: 3.786

4.  Diagnostic value of a single serum thyroglobulin determination on and off thyroid suppressive therapy in the follow-up of patients with differentiated thyroid cancer.

Authors:  F Pacini; R Lari; S Mazzeo; L Grasso; D Taddei; A Pinchera
Journal:  Clin Endocrinol (Oxf)       Date:  1985-10       Impact factor: 3.478

5.  Long-term results of treatment of 283 patients with lung and bone metastases from differentiated thyroid carcinoma.

Authors:  M Schlumberger; M Tubiana; F De Vathaire; C Hill; P Gardet; J P Travagli; P Fragu; J Lumbroso; B Caillou; C Parmentier
Journal:  J Clin Endocrinol Metab       Date:  1986-10       Impact factor: 5.958

6.  Serial serum thyroglobulin measurements in the management of differentiated thyroid carcinoma.

Authors:  E G Black; M C Sheppard; R Hoffenberg
Journal:  Clin Endocrinol (Oxf)       Date:  1987-07       Impact factor: 3.478

7.  Therapeutic doses of iodine-131 reveal undiagnosed metastases in thyroid cancer patients with detectable serum thyroglobulin levels.

Authors:  F Pacini; F Lippi; N Formica; R Elisei; S Anelli; C Ceccarelli; A Pinchera
Journal:  J Nucl Med       Date:  1987-12       Impact factor: 10.057

8.  Detection and treatment of lung metastases of differentiated thyroid carcinoma in patients with normal chest X-rays.

Authors:  M Schlumberger; O Arcangioli; J D Piekarski; M Tubiana; C Parmentier
Journal:  J Nucl Med       Date:  1988-11       Impact factor: 10.057

9.  The comparative value of serum thyroglobulin measurements and iodine 131 total body scans in the follow-up study of patients with treated differentiated thyroid cancer.

Authors:  M W Ashcraft; A J Van Herle
Journal:  Am J Med       Date:  1981-11       Impact factor: 4.965

10.  An international cooperative study evaluating serum thyroglobulin standards.

Authors:  A J Van Herle; I S Van Herle; M A Greipel
Journal:  J Clin Endocrinol Metab       Date:  1985-02       Impact factor: 5.958
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2.  False positive 131I total body scan due to an ectasia of the common carotidis.

Authors:  D Giuffrida; M R Garofalo; G Cacciaguerra; V Freni; A Ippolito; C Regalbuto; M G Santonocito; A Belfiore
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3.  Diagnostic 131I whole-body scintigraphy 1 year after thyroablative therapy in patients with differentiated thyroid cancer: correlation of results to the individual risk profile and long-term follow-up.

Authors:  Frank Berger; Ulla Friedrich; Peter Knesewitsch; Klaus Hahn
Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-11-18       Impact factor: 9.236

4.  Prognostic value of serial serum thyroglobulin determinations after total thyroidectomy for differentiated thyroid cancer.

Authors:  N Lima; H Cavaliere; E Tomimori; M Knobel; G Medeiros-Neto
Journal:  J Endocrinol Invest       Date:  2002-02       Impact factor: 4.256

5.  Does (131)I Radioactivity Interfere with Thyroglobulin Measurement in Patients Undergoing Radioactive Iodine Therapy with Recombinant Human TSH?

Authors:  Sohyun Park; Ji-In Bang; Ho-Young Lee; Sang-Eun Kim
Journal:  Nucl Med Mol Imaging       Date:  2015-01-27

Review 6.  Thyroid cancer: a review of treatment and follow-up.

Authors:  L Vini; C Harmer; V R McCready
Journal:  Ann Nucl Med       Date:  1996-02       Impact factor: 2.668

7.  Metastatic thyroid carcinoma of the adrenal gland.

Authors:  M E Girelli; D Casara; D Rubello; M Piccolo; A Piotto; M R Pelizzo; B Busnardo
Journal:  J Endocrinol Invest       Date:  1993-02       Impact factor: 4.256

8.  Evaluation of a new automated assay for high-sensitivity thyroglobulin measurement and comparison with two established high-sensitivity thyroglobulin assays.

Authors:  Martina Broecker-Preuss; Irina Mehnert; Elena Gilman; Ken Herrmann; Manuel Weber; Rainer Görges
Journal:  Pract Lab Med       Date:  2021-07-27
  8 in total

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