| Literature DB >> 20403350 |
Elisa Prieto-Lara1, Aurora Llanos-Méndez.
Abstract
A systematic review was performed to assess the safety and immunogenicity of the prepandemic H5N1 influenza vaccines licensed so far. A bibliographic search according to the COSI protocol was carried out and 8 of 235 potentially relevant publications were selected. Quality assessment was defined with both CASP and Jadad checklists. Taken together, the results from the present systematic review suggest that the inactivated split-virion formulation that includes a low antigen dose (3.8 microg) and an oil-in-water emulsion-based adjuvant, represents the best option in the case of a pandemic, due to its antigen-sparing capacity and its favorable safety profile. (c) 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID: 20403350 DOI: 10.1016/j.vaccine.2010.03.068
Source DB: PubMed Journal: Vaccine ISSN: 0264-410X Impact factor: 3.641