Literature DB >> 20401738

Simultaneous expression of Arabidopsis ρ-hydroxyphenylpyruvate dioxygenase and MPBQ methyltransferase in transgenic corn kernels triples the tocopherol content.

Shaista Naqvi1, Gemma Farré, Changfu Zhu, Gerhard Sandmann, Teresa Capell, Paul Christou.   

Abstract

The quantity and composition of tocopherols (compounds with vitamin E activity) vary widely among different plant species reflecting the expression, activity and substrate specificity of enzymes in the corresponding metabolic pathway. Two Arabidopsis cDNA clones corresponding to ρ-hydroxyphenylpyruvate dioxygenase (HPPD) and 2-methyl-6-phytylplastoquinol methyltransferase (MPBQ MT) were constitutively expressed in corn to further characterize the pathway and increase the kernel tocopherol content. Transgenic kernels contained up to 3 times as much γ-tocopherol as their wild type counterparts whereas other tocopherol isomers remained undetectable. Biofortification by metabolic engineering offers a sustainable alternative to vitamin E supplementation for the improvement of human health.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20401738     DOI： 10.1007/s11248-010-9393-6

Source DB:  PubMed          Journal:  Transgenic Res        ISSN： 0962-8819            Impact factor:   2.788


  13 in total

Review 1.  Transgenic strategies for the nutritional enhancement of plants.

Authors:  Changfu Zhu; Shaista Naqvi; Sonia Gomez-Galera; Ana M Pelacho; Teresa Capell; Paul Christou
Journal:  Trends Plant Sci       Date:  2007-11-19       Impact factor: 18.313

2.  Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways.

Authors:  Shaista Naqvi; Changfu Zhu; Gemma Farre; Koreen Ramessar; Ludovic Bassie; Jürgen Breitenbach; Dario Perez Conesa; Gaspar Ros; Gerhard Sandmann; Teresa Capell; Paul Christou
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-27       Impact factor: 11.205

Review 3.  Critical evaluation of strategies for mineral fortification of staple food crops.

Authors:  Sonia Gómez-Galera; Eduard Rojas; Duraialagaraja Sudhakar; Changfu Zhu; Ana M Pelacho; Teresa Capell; Paul Christou
Journal:  Transgenic Res       Date:  2009-08-15       Impact factor: 2.788

4.  Ubiquitin promoter-based vectors for high-level expression of selectable and/or screenable marker genes in monocotyledonous plants.

Authors:  A H Christensen; P H Quail
Journal:  Transgenic Res       Date:  1996-05       Impact factor: 2.788

5.  Human plasma and tissue alpha-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E.

Authors:  G W Burton; M G Traber; R V Acuff; D N Walters; H Kayden; L Hughes; K U Ingold
Journal:  Am J Clin Nutr       Date:  1998-04       Impact factor: 7.045

Review 6.  Vitamin E in humans: demand and delivery.

Authors:  M G Traber; H Sies
Journal:  Annu Rev Nutr       Date:  1996       Impact factor: 11.848

7.  Engineering vitamin E content: from Arabidopsis mutant to soy oil.

Authors:  Alison L Van Eenennaam; Kim Lincoln; Timothy P Durrett; Henry E Valentin; Christine K Shewmaker; Greg M Thorne; Jian Jiang; Susan R Baszis; Charlene K Levering; Eric D Aasen; Ming Hao; Joshua C Stein; Susan R Norris; Robert L Last
Journal:  Plant Cell       Date:  2003-11-20       Impact factor: 11.277

8.  IMPROVING THE NUTRIENT COMPOSITION OF PLANTS TO ENHANCE HUMAN NUTRITION AND HEALTH1.

Authors:  Michael A. Grusak; Dean DellaPenna
Journal:  Annu Rev Plant Physiol Plant Mol Biol       Date:  1999-06

9.  Localization and synthesis of prenylquinones in isolated outer and inner envelope membranes from spinach chloroplasts.

Authors:  J Soll; G Schultz; J Joyard; R Douce; M A Block
Journal:  Arch Biochem Biophys       Date:  1985-04       Impact factor: 4.013

10.  Combinatorial genetic transformation generates a library of metabolic phenotypes for the carotenoid pathway in maize.

Authors:  Changfu Zhu; Shaista Naqvi; Jürgen Breitenbach; Gerhard Sandmann; Paul Christou; Teresa Capell
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-14       Impact factor: 11.205
View more
  14 in total

1.  The contribution of transgenic plants to better health through improved nutrition: opportunities and constraints.

Authors:  Eduard Pérez-Massot; Raviraj Banakar; Sonia Gómez-Galera; Uxue Zorrilla-López; Georgina Sanahuja; Gemma Arjó; Bruna Miralpeix; Evangelia Vamvaka; Gemma Farré; Sol Maiam Rivera; Svetlana Dashevskaya; Judit Berman; Maite Sabalza; Dawei Yuan; Chao Bai; Ludovic Bassie; Richard M Twyman; Teresa Capell; Paul Christou; Changfu Zhu
Journal:  Genes Nutr       Date:  2012-08-29       Impact factor: 5.523

2.  Improvement of vitamin E quality and quantity in tobacco and lettuce by chloroplast genetic engineering.

Authors:  Yukinori Yabuta; Hiroyuki Tanaka; Sahoko Yoshimura; Akiko Suzuki; Masahiro Tamoi; Takanori Maruta; Shigeru Shigeoka
Journal:  Transgenic Res       Date:  2012-09-19       Impact factor: 2.788

3.  Increased α-tocotrienol content in seeds of transgenic rice overexpressing Arabidopsis γ-tocopherol methyltransferase.

Authors:  Gui-Yun Zhang; Ru-Ru Liu; Geng Xu; Peng Zhang; Yin Li; Ke-Xuan Tang; Guo-Hua Liang; Qiao-Quan Liu
Journal:  Transgenic Res       Date:  2012-07-05       Impact factor: 2.788

4.  Transcriptional regulation of tocopherol biosynthesis in tomato.

Authors:  Leandro Quadrana; Juliana Almeida; Santiago N Otaiza; Tomas Duffy; Junia V Corrêa da Silva; Fabiana de Godoy; Ramon Asís; Luisa Bermúdez; Alisdair R Fernie; Fernando Carrari; Magdalena Rossi
Journal:  Plant Mol Biol       Date:  2012-12-18       Impact factor: 4.076

5.  GmTMT2a from soybean elevates the α-tocopherol content in corn and Arabidopsis.

Authors:  Lan Zhang; Yanzhong Luo; Yongxing Zhu; Liang Zhang; Wei Zhang; Rumei Chen; Miaoyun Xu; Yunliu Fan; Lei Wang
Journal:  Transgenic Res       Date:  2013-05-04       Impact factor: 2.788

6.  Overexpression of the maize γ-tocopherol methyltransferase gene (ZmTMT) increases α-tocopherol content in transgenic Arabidopsis and maize seeds.

Authors:  Lan Zhang; Yanzhong Luo; Bin Liu; Liang Zhang; Wei Zhang; Rumei Chen; Lei Wang
Journal:  Transgenic Res       Date:  2019-10-31       Impact factor: 2.788

Review 7.  Plastoquinone and Ubiquinone in Plants: Biosynthesis, Physiological Function and Metabolic Engineering.

Authors:  Miaomiao Liu; Shanfa Lu
Journal:  Front Plant Sci       Date:  2016-12-16       Impact factor: 5.753

8.  P-HYDROXYPHENYLPYRUVATE DIOXYGENASE from Medicago sativa is involved in vitamin E biosynthesis and abscisic acid-mediated seed germination.

Authors:  Jishan Jiang; Zhihong Chen; Liping Ban; Yudi Wu; Jianping Huang; Jinfang Chu; Shuang Fang; Zan Wang; Hongwen Gao; Xuemin Wang
Journal:  Sci Rep       Date:  2017-01-13       Impact factor: 4.379

9.  Transgenic rice grains expressing a heterologous ρ-hydroxyphenylpyruvate dioxygenase shift tocopherol synthesis from the γ to the α isoform without increasing absolute tocopherol levels.

Authors:  Gemma Farré; Duraialagaraja Sudhakar; Shaista Naqvi; Gerhard Sandmann; Paul Christou; Teresa Capell; Changfu Zhu
Journal:  Transgenic Res       Date:  2012-02-24       Impact factor: 2.788

Review 10.  Vitamins in Cereals: A Critical Review of Content, Health Effects, Processing Losses, Bioaccessibility, Fortification, and Biofortification Strategies for Their Improvement.

Authors:  Monika Garg; Anjali Sharma; Shreya Vats; Vandita Tiwari; Anita Kumari; Vibhu Mishra; Meena Krishania
Journal:  Front Nutr       Date:  2021-06-16
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.