Literature DB >> 20401299

Rituximab-induced polymorphic ventricular tachycardia.

Joseph T Poterucha1, Mark Westberg, Pamela Nerheim, James P Lovell.   

Abstract

The anti-CD20 monoclonal antibody rituximab is an effective treatment for small lymphocytic lymphoma; however, it has been associated with infusion reactions, including cardiac arrhythmias. Severe cardiac arrhythmia is an adverse reaction that is related to rituximab chemotherapy, and more investigation is warranted into the adverse reactions of rituximab that involve cardiac conduction abnormalities. Herein, we report what we believe to be the 1st case of symptomatic polymorphic ventricular tachycardia to have occurred during an initial infusion of rituximab.

Entities:  

Keywords:  Antibodies, monoclonal/administration & dosage/adverse effects; cardiac pacing, artificial; electrocardiography; heart rate; long QT syndrome/diagnosis/etiology; lymphoma, B-cell/drug therapy; rituximab; tachycardia, ventricular/chemically induced/mortality; tachycardia/diagnosis; torsades de pointes/diagnosis/etiology

Mesh:

Substances:

Year:  2010        PMID: 20401299      PMCID: PMC2851419     

Source DB:  PubMed          Journal:  Tex Heart Inst J        ISSN: 0730-2347


  14 in total

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