Literature DB >> 2039940

Large neurons in the neostriatum in Alzheimer's disease and progressive supranuclear palsy: a topographic, histologic and ultrastructural investigation.

K Oyanagi1, H Takahashi, K Wakabayashi, F Ikuta.   

Abstract

Large neurons in the neostriatum of patients with Alzheimer's disease (AD) and progressive supranuclear palsy (PSP) were investigated topographically, histologically and ultrastructurally. The number of large neurons whose nuclear area is greater than 101 microns2 was uniformly decreased in the neostriatum in PSP, but the decrease of these neurons in AD appeared to be more marked in the nucleus accumbens. Most of the remaining large neurons in both diseases contained neurofibrillary tangles (NFTs). In addition, some of the small neurons in PSP were positive for tau-immunostaining. Curly fibers were frequently observed in AD, but were absent in PSP. Ultrastructurally, NFTs in AD were composed mainly of paired helical filaments, whereas those in PSP contained straight tubules.

Entities:  

Mesh：

Year:  1991        PMID： 2039940     DOI： 10.1016/0006-8993(91)90057-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

1.  Corticobasal degeneration with neither argyrophilic inclusions nor tau abnormalities: a new subgroup?

Authors:  K Kawasaki; K Iwanaga; K Wakabayashi; M Yamada; H Nagai; J Idezuka; Y Homma; F Ikuta
Journal:  Acta Neuropathol       Date:  1996       Impact factor: 17.088

2.  Does methylmercury intoxication induce arteriosclerosis in humans? A pathological investigation of 22 autopsy cases in Niigata, Japan.

Authors:  K Oyanagi; A Furuta; E Ohama; F Ikuta
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088

Review 3.  Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration.

Authors:  D W Dickson
Journal:  J Neurol       Date:  1999-09       Impact factor: 4.849

Review 4.  Neuropathology of parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam: an update.

Authors:  K Oyanagi; M Wada
Journal:  J Neurol       Date:  1999-09       Impact factor: 4.849

5.  Ultrastructural instability of paired helical filaments from corticobasal degeneration as examined by scanning transmission electron microscopy.

Authors:  H Ksiezak-Reding; E Tracz; L S Yang; D W Dickson; M Simon; J S Wall
Journal:  Am J Pathol       Date:  1996-08       Impact factor: 4.307

6.  Corticobasal degeneration: etiopathological significance of the cytoskeletal alterations.

Authors:  K Wakabayashi; K Oyanagi; T Makifuchi; F Ikuta; A Homma; Y Homma; Y Horikawa; S Tokiguchi
Journal:  Acta Neuropathol       Date:  1994       Impact factor: 17.088

7.  The neostriatum and nucleus accumbens in parkinsonism-dementia complex of Guam: a pathological comparison with Alzheimer's disease and progressive supranuclear palsy.

Authors:  K Oyanagi; T Makifuchi; T Ohtoh; K M Chen; D C Gajdusek; T N Chase; F Ikuta
Journal:  Acta Neuropathol       Date:  1994       Impact factor: 17.088

8.  Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: The Hisayama study.

Authors:  Hideomi Hamasaki; Hiroyuki Honda; Satoshi O Suzuki; Masahiro Shijo; Tomoyuki Ohara; Yozo Hatabe; Tsuyoshi Okamoto; Toshiharu Ninomiya; Toru Iwaki
Journal:  Alzheimers Dement (Amst)       Date:  2019-06-06

9.  Tau accumulation in the nucleus accumbens in tangle-predominant dementia.

Authors:  Ito Kawakami; Masato Hasegawa; Tetsuaki Arai; Kenji Ikeda; Kenichi Oshima; Kazuhiro Niizato; Naoya Aoki; Katsuse Omi; Shinji Higashi; Masato Hosokawa; Yoshio Hirayasu; Haruhiko Akiyama
Journal:  Acta Neuropathol Commun       Date:  2014-04-08       Impact factor: 7.801
  9 in total

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