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Literature DB >> 20398743

Study on the structure-function relationship of 20(S)-panaxadiol and its epimeric derivatives in myocardial injury induced by isoproterenol.

Tian Wang¹, Qingguo Meng, Jiangfeng Zhang, Yi Bi, Naicai Jiang.

Abstract

This study was aimed to investigate structure-function relationship of 20(S)-panaxadiol (PD) and its epimeric derivatives ((20S, 24S)-epoxy-dammarane-3β, 12β, 25-triol, PDD1 and (20S, 24R)-epoxy-dammarane-3β, 12β, 25-triol, PDD2) in myocardial ischemia injury in rats. It was shown that PD and PDD2 resulted in a reduction in creatine kinase activity. PD and PDD2 inhibited the elevation of malondialdehyde content, the reduction of superoxide dismutase and glutathione peroxidase activities. The pathohistological changes were ameliorated by PD and PDD2. The configuration of C-24 of funan ring was linked to the pharmacological action of 20(S)-panaxadiol and its epimeric derivatives.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2010 PMID： 20398743 DOI： 10.1016/j.fitote.2010.04.005

Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882

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Cited

13 in total

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10. Stereoselective property of 20(S)-protopanaxadiol ocotillol type epimers affects its absorption and also the inhibition of P-glycoprotein.

Authors: Wenyan Wang; Xiangmeng Wu; Li Wang; Qingguo Meng; Wanhui Liu
Journal: PLoS One Date: 2014-06-02 Impact factor: 3.240

Study on the structure-function relationship of 20(S)-panaxadiol and its epimeric derivatives in myocardial injury induced by isoproterenol.

1. Synthesis and Structure-Activity Relationship of Pyxinol Derivatives as Novel Anti-Inflammatory Agents.

2. The Active Compounds of Yixin Ningshen Tablet and Their Potential Action Mechanism in Treating Coronary Heart Disease- A Network Pharmacology and Proteomics Approach.

3. Synthesis, characterization and cytotoxic activity evaluation of ginsengdiol oxidation and nitrogen hybrid derivatives.

4. (3R,6R,12R,20S,24S)-3,6,12-Triacetyl-20,24-ep-oxy-dammarane-3,6,12,25-tetra-ol.

5. (3R,6R,12R,20S,24R)-20,24-Ep-oxy-dammarane-3,6,12,25-tetra-ol.

6. (3S,12R,20S,24R)-20,24-Ep-oxy-dammarane-3,12,25-triol.

7. Ginsenoside-Rb1 Inhibition of VEGF Release - Structure and Activity Relations (SAR) Perspective.

Review 8. Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.

Review 9. Structural characteristics, bioavailability and cardioprotective potential of saponins.

10. Stereoselective property of 20(S)-protopanaxadiol ocotillol type epimers affects its absorption and also the inhibition of P-glycoprotein.