Literature DB >> 20398721

Protective effect of sesamol on the pulmonary inflammatory response and lung injury in endotoxemic rats.

Pei-Yi Chu1, Se-Ping Chien, Dur-Zong Hsu, Ming-Yie Liu.   

Abstract

We investigated the effect of sesamol on systemic lipopolysaccharide (LPS)-induced lung inflammation in rats. Sesamol decreased lung edema and injury, significantly decreased LPS-induced cell counts, protein concentration, tumor necrosis factor (TNF)-alpha, and nitrite levels in bronchoalveolar lavage fluid, and decreased the TNF-alpha, nitrite, and inducible nitric oxide synthase protein expression in lung tissue. Further, sesamol significantly inhibited LPS-induced TNF-alpha, nitrite, inducible nitric oxide synthase expression, and nuclear factor-kappaB activation levels in primary alveolar macrophages. We hypothesize that sesamol attenuates systemic LPS-induced lung inflammation by inhibiting the alveolar macrophage inflammatory response in rats. 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20398721     DOI： 10.1016/j.fct.2010.04.014

Source DB:  PubMed          Journal:  Food Chem Toxicol        ISSN： 0278-6915            Impact factor:   6.023


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