UNLABELLED: The use of protons for curative treatment of prostate cancer is increasing, either as a single treatment modality or in combination with conventional radiotherapy. The proximity between prostate (target) and rectum (organ at risk) often leads to a compromise between dose to target and organ at risk. MATERIAL AND METHODS: The present study describes a method where the distance between prostate and rectum is increased by retraction of the rectum in dorsal direction. Comparative treatment plans with and without retraction of the rectum in the same patients have been studied. Nine patients with biopsy proven, localised adenocarcinoma of the prostate were studied. A cylindrical rod of Perspex was inserted into the rectum. This device allows the rectum to be retracted posteriorly. The patients were given a proton boost of 20 Gy in four fractions of 5 Gy in addition to a conventional photon beam treatment to a dose of 50 Gy in 25 fractions of 2 Gy. RESULTS: Comparative treatment planning shows that the treatment plan with rectal retraction significantly reduces (p<0.01) the volume of the rectal wall receiving high doses (equal to 70 Gy in 2 Gy fractions) in all patients. CONCLUSIONS: The proton boost treatment with retraction of rectum during treatment decreases the rectal dose substantially. This is expected to reduce rectal side effects.
UNLABELLED: The use of protons for curative treatment of prostate cancer is increasing, either as a single treatment modality or in combination with conventional radiotherapy. The proximity between prostate (target) and rectum (organ at risk) often leads to a compromise between dose to target and organ at risk. MATERIAL AND METHODS: The present study describes a method where the distance between prostate and rectum is increased by retraction of the rectum in dorsal direction. Comparative treatment plans with and without retraction of the rectum in the same patients have been studied. Nine patients with biopsy proven, localised adenocarcinoma of the prostate were studied. A cylindrical rod of Perspex was inserted into the rectum. This device allows the rectum to be retracted posteriorly. The patients were given a proton boost of 20 Gy in four fractions of 5 Gy in addition to a conventional photon beam treatment to a dose of 50 Gy in 25 fractions of 2 Gy. RESULTS: Comparative treatment planning shows that the treatment plan with rectal retraction significantly reduces (p<0.01) the volume of the rectal wall receiving high doses (equal to 70 Gy in 2 Gy fractions) in all patients. CONCLUSIONS: The proton boost treatment with retraction of rectum during treatment decreases the rectal dose substantially. This is expected to reduce rectal side effects.
Authors: Kimberley Legge; Peter B Greer; Daryl J O'Connor; Lee Wilton; Matthew Richardson; Perry Hunter; Alex Wilfert; Jarad Martin; Anatoly Rosenfeld; Dean Cutajar Journal: Radiat Oncol Date: 2017-02-27 Impact factor: 3.481
Authors: Matthew Richardson; Mark Sidhom; Sarah Gallagher; Mel Grand; David Pryor; Joseph Bucci; Lee Wilton; Sankar Arumugam; Sarah Keats; Jarad M Martin Journal: BMC Cancer Date: 2018-05-24 Impact factor: 4.430
Authors: Angèle Dubouloz; Michel Rouzaud; Lev Tsvang; Wilko Verbakel; Mikko Björkqvist; Nadine Linthout; Joana Lencart; Juan María Pérez-Moreno; Zeynep Ozen; Lluís Escude; Thomas Zilli; Raymond Miralbell Journal: Radiat Oncol Date: 2018-06-19 Impact factor: 3.481
Authors: Kimberley Legge; Doan Nguyen; Jin Aun Ng; Lee Wilton; Matthew Richardson; Jeremy Booth; Paul Keall; Darryl J O'Connor; Peter Greer; Jarad Martin Journal: J Appl Clin Med Phys Date: 2017-09-27 Impact factor: 2.102