Literature DB >> 2039710

Expression of the cluster 1 antigen (neural cell adhesion molecule) in neuroectodermal tumours.

K Patel1, G Frost, F Kiely, E Phimister, H B Coakham, J T Kemshead.   

Abstract

In this study, we have investigated the expression of the neural cell adhesion molecule (NCAM) in the human brain, primary brain tumours and neuroblastoma. Adult brain was found to express discrete isoforms of 180, 170, 140 and 120 kDa, which on neuraminidase treatment resolved into bands of 180, 170, 140, 120 and 95 kDa. Primary brain tumours such as Schwannoma and medulloblastoma expressed embryonic NCAM characterised by a high level of glycosylation, whereas other tumours, e.g. astrocytoma, meningioma, glioma and oligodendroglioma expressed adult NCAM. Post-neuraminidase treatment, differential expression of the 180, 170, 140, 120 and 95 kDa isoforms were noted in these various tumour types. On the other hand, neuroblastoma cell lines were found to express only embryonic NCAM, which after neuraminidase treatment resulted in differential presence of only 180, 140 and 120 kDa proteins.

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Year:  1991        PMID： 2039710      PMCID： PMC2204107     

Source DB:  PubMed          Journal:  Br J Cancer Suppl        ISSN： 0306-9443


  8 in total

Review 1.  Cell adhesion molecules in neural development.

Authors:  D Linnemann; E Bock
Journal:  Dev Neurosci       Date:  1989       Impact factor: 2.984

2.  Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing.

Authors:  B A Cunningham; J J Hemperly; B A Murray; E A Prediger; R Brackenbury; G M Edelman
Journal:  Science       Date:  1987-05-15       Impact factor: 47.728

3.  Differences in the carbohydrate structures of neural cell-adhesion molecules from adult and embryonic chicken brains.

Authors:  J B Rothbard; R Brackenbury; B A Cunningham; G M Edelman
Journal:  J Biol Chem       Date:  1982-09-25       Impact factor: 5.157

4.  Neural cell adhesion molecule (NCAM) is the antigen recognized by monoclonal antibodies of similar specificity in small-cell lung carcinoma and neuroblastoma.

Authors:  K Patel; S E Moore; G Dickson; R J Rossell; P C Beverley; J T Kemshead; F S Walsh
Journal:  Int J Cancer       Date:  1989-10-15       Impact factor: 7.396

5.  Human muscle neural cell adhesion molecule (N-CAM): identification of a muscle-specific sequence in the extracellular domain.

Authors:  G Dickson; H J Gower; C H Barton; H M Prentice; V L Elsom; S E Moore; R D Cox; C Quinn; W Putt; F S Walsh
Journal:  Cell       Date:  1987-09-25       Impact factor: 41.582

6.  Alternative splicing generates a secreted form of N-CAM in muscle and brain.

Authors:  H J Gower; C H Barton; V L Elsom; J Thompson; S E Moore; G Dickson; F S Walsh
Journal:  Cell       Date:  1988-12-23       Impact factor: 41.582

7.  Four exons encode a 93-base-pair insert in three neural cell adhesion molecule mRNAs specific for chicken heart and skeletal muscle.

Authors:  E A Prediger; S Hoffman; G M Edelman; B A Cunningham
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

8.  Differential exon usage involving an unusual splicing mechanism generates at least eight types of NCAM cDNA in mouse brain.

Authors:  M J Santoni; D Barthels; G Vopper; A Boned; C Goridis; W Wille
Journal:  EMBO J       Date:  1989-02       Impact factor: 11.598
  8 in total
  5 in total

1.  Integrins mediate adhesion of medulloblastoma cells to tenascin and activate pathways associated with survival and proliferation.

Authors:  Paul Fiorilli; Darren Partridge; Izabela Staniszewska; Jin Y Wang; Maja Grabacka; Kelvin So; Cezary Marcinkiewicz; Krzysztof Reiss; Kamel Khalili; Sidney E Croul
Journal:  Lab Invest       Date:  2008-09-15       Impact factor: 5.662

2.  Neural cell adhesion molecule isoform 140 declines with rise of WHO grade in human gliomas and serves as indicator for the invasion zone of multiform glioblastomas and brain metastases.

Authors:  Pedro Duenisch; Rupert Reichart; Ulrike Mueller; Michael Brodhun; Rolf Bjerkvig; Bernd Romeike; Jan Walter; Christian Herbold; Christian R A Regenbrecht; Rolf Kalff; Susanne A Kuhn
Journal:  J Cancer Res Clin Oncol       Date:  2010-05-04       Impact factor: 4.553

3.  Neural cell adhesion molecule expression in human pituitary adenomas.

Authors:  B K Kleinschmidt-DeMasters; D R Conway; W A Franklin; K O Lillehei; C A Kruse
Journal:  J Neurooncol       Date:  1995       Impact factor: 4.130

Review 4.  Combinatorial approaches for the identification of brain drug delivery targets.

Authors:  Charles C Stutz; Xiaobin Zhang; Eric V Shusta
Journal:  Curr Pharm Des       Date:  2014       Impact factor: 3.116

5.  Immunocytochemical assessment of bone marrow aspirates for monitoring response to chemotherapy in small-cell lung cancer patients.

Authors:  G Pelosi; F Pasini; C Ottensmeier; F Pavanel; E Bresaola; A Bonetti; F Fraggetta; A Terzi; A Iannucci; G L Cetto
Journal:  Br J Cancer       Date:  1999-12       Impact factor: 7.640
  5 in total

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