Literature DB >> 20396769

Methodological guidelines for genetic safety testing of cell transplants.

N P Bochkov1, V A Nikitina, E S Voronina, N P Kuleshov.   

Abstract

A combination of karyotyping and aneuploidy analysis by interphase fluorescent in situ hybridization is a sensitive method for evaluation of genetic stability of stem cell cultures. The methodology and specific features of preparing and analyzing the cytogenetic preparations are described as exemplified by human multipotent mesenchymal stromal cells.

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Year:  2009        PMID： 20396769     DOI： 10.1007/s10517-010-0793-7

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  2 in total

1.  Clonal chromosomal and genomic instability during human multipotent mesenchymal stromal cells long-term culture.

Authors:  Victoria Nikitina; Tatiana Astrelina; Vladimir Nugis; Aleksandr Ostashkin; Tatiana Karaseva; Ekaterina Dobrovolskaya; Dariya Usupzhanova; Yulia Suchkova; Elena Lomonosova; Sergey Rodin; Vitaliy Brunchukov; Stanislav Lauk-Dubitskiy; Valentin Brumberg; Anastasia Machova; Irina Kobzeva; Andrey Bushmanov; Aleksandr Samoilov
Journal:  PLoS One       Date:  2018-02-12       Impact factor: 3.240

2.  A model study for the manufacture and validation of clinical-grade deciduous dental pulp stem cells for chronic liver fibrosis treatment.

Authors:  Tsuyoshi Iwanaka; Takayoshi Yamaza; Soichiro Sonoda; Koichiro Yoshimaru; Toshiharu Matsuura; Haruyoshi Yamaza; Shouichi Ohga; Yoshinao Oda; Tomoaki Taguchi
Journal:  Stem Cell Res Ther       Date:  2020-03-25       Impact factor: 6.832
  2 in total

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