Literature DB >> 20396652

Analysis of arsenical metabolites in biological samples.

Araceli Hernandez-Zavala1, Zuzana Drobna, Miroslav Styblo, David J Thomas.   

Abstract

Quantitation of iAs and its methylated metabolites in biological samples provides dosimetric information needed to understand dose-response relations. Here, methods are described for separation of inorganic and mono-, di-, and trimethylated arsenicals by thin layer chromatography. This method has been extensively used to track the metabolism of the radionuclide [(73)As] in a variety of in vitro assay systems. In addition, a hydride generation-cryotrapping-gas chromatography-atomic absorption spectrometric method is described for the quantitation of arsenicals in biological samples. This method uses pH-selective hydride generation to differentiate among arsenicals containing trivalent or pentavalent arsenic.

Entities:  

Keywords:  [73As]; arsenic; arsenic oxidation state; hydride generation-cryotrapping-gas chromatography-atomic absorption spectrometry; methylated arsenicals; pH-selective hydride generation; thin layer chromatography

Mesh：

Substances：

Year:  2009        PMID： 20396652      PMCID： PMC2853037          DOI： 10.1002/0471140856.tx0433s42

Source DB:  PubMed          Journal:  Curr Protoc Toxicol        ISSN： 1934-9254


  11 in total

1.  Liberation and analysis of protein-bound arsenicals.

Authors:  M Styblo; M F Hughes; D J Thomas
Journal:  J Chromatogr B Biomed Appl       Date:  1996-02-23

2.  Preparation and purification of 74As-labeled arsenate and arsenite for use in biological experiments.

Authors:  P F Reay; C J Asher
Journal:  Anal Biochem       Date:  1977-04       Impact factor: 3.365

3.  Determination of trivalent methylated arsenicals in biological matrices.

Authors:  L M Del Razo; M Styblo; W R Cullen; D J Thomas
Journal:  Toxicol Appl Pharmacol       Date:  2001-08-01       Impact factor: 4.219

4.  Glutathione modulates recombinant rat arsenic (+3 oxidation state) methyltransferase-catalyzed formation of trimethylarsine oxide and trimethylarsine.

Authors:  Stephen B Waters; Vicenta Devesa; Michael W Fricke; John T Creed; Miroslav Stýblo; David J Thomas
Journal:  Chem Res Toxicol       Date:  2004-12       Impact factor: 3.739

5.  Changes in the chemical speciation of arsenic following ingestion by man.

Authors:  E A Crecelius
Journal:  Environ Health Perspect       Date:  1977-08       Impact factor: 9.031

6.  Speciation analysis of arsenic in biological matrices by automated hydride generation-cryotrapping-atomic absorption spectrometry with multiple microflame quartz tube atomizer (multiatomizer).

Authors:  Araceli Hernández-Zavala; Tomáš Matoušek; Zuzana Drobná; David S Paul; Felecia Walton; Blakely M Adair; Dědina Jiří; David J Thomas; Miroslav Stýblo
Journal:  J Anal At Spectrom       Date:  2008       Impact factor: 4.023

7.  Identification of methylated metabolites of inorganic arsenic by thin-layer chromatography.

Authors:  M Stýblo; M Delnomdedieu; M F Hughes; D J Thomas
Journal:  J Chromatogr B Biomed Appl       Date:  1995-06-09

8.  Methylated forms of arsenic in the environment.

Authors:  R S Braman; C C Foreback
Journal:  Science       Date:  1973-12-21       Impact factor: 47.728

9.  Oxidation State Specific Generation of Arsines from Methylated Arsenicals Based on L- Cysteine Treatment in Buffered Media for Speciation Analysis by Hydride Generation - Automated Cryotrapping - Gas Chromatography-Atomic Absorption Spectrometry with the Multiatomizer.

Authors:  Tomáš Matoušek; Araceli Hernández-Zavala; Milan Svoboda; Lenka Langrová; Blakely M Adair; Zuzana Drobná; David J Thomas; Miroslav Stýblo; Jiří Dědina
Journal:  Spectrochim Acta Part B At Spectrosc       Date:  2008-03       Impact factor: 3.752

10.  Study of inorganic arsenic methylation by rat liver in vitro: relevance for the interpretation of observations in man.

Authors:  J P Buchet; R Lauwerys
Journal:  Arch Toxicol       Date:  1985-06       Impact factor: 5.153
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  3 in total

1.  Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling.

Authors:  Kathryn A Bailey; Jessica Laine; Julia E Rager; Elizabeth Sebastian; Andrew Olshan; Lisa Smeester; Zuzana Drobná; Miroslav Styblo; Marisela Rubio-Andrade; Gonzalo García-Vargas; Rebecca C Fry
Journal:  Toxicol Sci       Date:  2014-03-27       Impact factor: 4.849

2.  Prenatal arsenic exposure and the epigenome: altered microRNAs associated with innate and adaptive immune signaling in newborn cord blood.

Authors:  Julia E Rager; Kathryn A Bailey; Lisa Smeester; Sloane K Miller; Joel S Parker; Jessica E Laine; Zuzana Drobná; Jenna Currier; Christelle Douillet; Andrew F Olshan; Marisela Rubio-Andrade; Miroslav Stýblo; Gonzalo García-Vargas; Rebecca C Fry
Journal:  Environ Mol Mutagen       Date:  2013-12-10       Impact factor: 3.216

3.  Maternal serum concentrations of one-carbon metabolism factors modify the association between biomarkers of arsenic methylation efficiency and birth weight.

Authors:  Jeliyah Clark; Paige Bommarito; Miroslav Stýblo; Marisela Rubio-Andrade; Gonzalo G García-Vargas; Mary V Gamble; Rebecca C Fry
Journal:  Environ Health       Date:  2022-07-14       Impact factor: 7.123
  3 in total

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