| Literature DB >> 20394744 |
Juan Qu1, Danyi Wang, Cynthia L Grosskreutz.
Abstract
Glaucoma is a disease in which retinal ganglion cells (RGCs) die leading ultimately to blindness. Over the past decade and a half, information has begun to emerge regarding specific molecular responses of the retina to conditions of elevated intraocular pressure (IOP). It is now clear that the state of the RGC in glaucoma depends on a balance of pro-survival and pro-death pathways in the retina and details of these responses are still being worked out. In this review, we will discuss the evidence supporting the involvement of specific apoptotic cascades as well as the insults that trigger RGC apoptosis. In addition, we will present evidence supporting the existence of endogenous protective mechanisms as well as exogenous neuroprotective strategies. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20394744 PMCID： PMC3378677 DOI： 10.1016/j.exer.2010.04.002
Source DB: PubMed Journal: Exp Eye Res ISSN： 0014-4835 Impact factor: 3.467