BACKGROUND & AIM: Uptake, cytotoxicity and interaction of improved superparamagnetic iron oxide nanoparticles were studied in cells, tissues and organs after single and multiple exposures. MATERIAL & METHOD: We prepared dimercaptosuccinic acid-coated iron oxide nanoparticles by thermal decomposition in organic medium, resulting in aqueous suspensions with a small hydrodynamic size (< 100 nm), high saturation magnetization and susceptibility, high nuclear magnetic resonance contrast and low cytotoxicity. RESULTS: In vitro and in vivo behavior showed that these nanoparticles are efficient carriers for drug delivery to the liver and brain that can be combined with MRI detection.
BACKGROUND & AIM: Uptake, cytotoxicity and interaction of improved superparamagnetic iron oxide nanoparticles were studied in cells, tissues and organs after single and multiple exposures. MATERIAL & METHOD: We prepared dimercaptosuccinic acid-coated iron oxide nanoparticles by thermal decomposition in organic medium, resulting in aqueous suspensions with a small hydrodynamic size (< 100 nm), high saturation magnetization and susceptibility, high nuclear magnetic resonance contrast and low cytotoxicity. RESULTS: In vitro and in vivo behavior showed that these nanoparticles are efficient carriers for drug delivery to the liver and brain that can be combined with MRI detection.
Authors: Fernando Herranz; Beatriz Salinas; Hugo Groult; Juan Pellico; Ana V Lechuga-Vieco; Riju Bhavesh; J Ruiz-Cabello Journal: Nanomaterials (Basel) Date: 2014-06-05 Impact factor: 5.076
Authors: Charalampos Tsoukalas; Dimitrios Psimadas; George A Kastis; Vassilis Koutoulidis; Adrian L Harris; Maria Paravatou-Petsotas; Maria Karageorgou; Lars R Furenlid; Lia A Moulopoulos; Dimosthenis Stamopoulos; Penelope Bouziotis Journal: Front Chem Date: 2018-06-20 Impact factor: 5.221
Authors: Vitalii Patsula; Daniel Horák; Jan Kučka; Hana Macková; Volodymyr Lobaz; Pavla Francová; Vít Herynek; Tomáš Heizer; Petr Páral; Luděk Šefc Journal: Sci Rep Date: 2019-07-24 Impact factor: 4.379