BACKGROUND: The outcome of orthotopic liver transplantation (OLT) with controlled graft donation after cardiac death (DCD) is usually inferior to that with graft donation after brain death (DBD). This study compared outcomes from OLT with DBD versus controlled DCD donors with predefined restrictive acceptance criteria. METHODS: All adult recipients in the Netherlands in 2001-2006 with full-size OLT from DCD (n = 55) and DBD (n = 471) donors were included. Kaplan-Meier, log rank and Cox regression analyses were used. RESULTS: One- and 3-year patient survival rates were similar for DCD (85 and 80 per cent) and DBD (86.3 and 80.8 per cent) transplants (P = 0.763), as were graft survival rates (74 and 68 per cent versus 80.4 and 74.5 per cent; P = 0.212). The 3-year cumulative percentage of surviving grafts developing non-anastomotic biliary strictures was 31 per cent after DCD and 9.7 per cent after DBD transplantation (P < 0.001). The retransplantation rate was similar overall (P = 0.081), but that for biliary stricture was higher in the DCD group (P < 0.001). Risk factors for 1-year graft loss after DBD OLT were transplant centre, recipient warm ischaemia time and donor with severe head trauma. After DCD OLT they were transplant centre, donor warm ischaemia time and cold ischaemia time. DCD graft was a risk factor for non-anastomotic biliary stricture. CONCLUSION: OLT using controlled DCD grafts and restrictive criteria can result in patient and graft survival rates similar to those of DBD OLT, despite a higher risk of biliary stricture. Copyright 2010 British Journal of Surgery Society Ltd.
BACKGROUND: The outcome of orthotopic liver transplantation (OLT) with controlled graft donation after cardiac death (DCD) is usually inferior to that with graft donation after brain death (DBD). This study compared outcomes from OLT with DBD versus controlled DCD donors with predefined restrictive acceptance criteria. METHODS: All adult recipients in the Netherlands in 2001-2006 with full-size OLT from DCD (n = 55) and DBD (n = 471) donors were included. Kaplan-Meier, log rank and Cox regression analyses were used. RESULTS: One- and 3-year patient survival rates were similar for DCD (85 and 80 per cent) and DBD (86.3 and 80.8 per cent) transplants (P = 0.763), as were graft survival rates (74 and 68 per cent versus 80.4 and 74.5 per cent; P = 0.212). The 3-year cumulative percentage of surviving grafts developing non-anastomotic biliary strictures was 31 per cent after DCD and 9.7 per cent after DBD transplantation (P < 0.001). The retransplantation rate was similar overall (P = 0.081), but that for biliary stricture was higher in the DCD group (P < 0.001). Risk factors for 1-year graft loss after DBD OLT were transplant centre, recipient warm ischaemia time and donor with severe head trauma. After DCD OLT they were transplant centre, donor warm ischaemia time and cold ischaemia time. DCD graft was a risk factor for non-anastomotic biliary stricture. CONCLUSION: OLT using controlled DCD grafts and restrictive criteria can result in patient and graft survival rates similar to those of DBD OLT, despite a higher risk of biliary stricture. Copyright 2010 British Journal of Surgery Society Ltd.
Authors: J J Vos; T W L Scheeren; D J Lukes; M T de Boer; H G D Hendriks; J K G Wietasch Journal: J Clin Monit Comput Date: 2013-05-16 Impact factor: 2.502
Authors: Eno-Obong I Essien; Nehu Parimi; Jennifer Gutwald-Miller; Tyree Nutter; Thomas M Scalea; Deborah M Stein Journal: World J Surg Date: 2017-11 Impact factor: 3.352
Authors: Ali Canbay; Frank Tacke; Johannes Hadem; Christian Trautwein; Guido Gerken; Michael P Manns Journal: Dtsch Arztebl Int Date: 2011-10-21 Impact factor: 5.594
Authors: Negin Karimian; Alix P M Matton; Andrie C Westerkamp; Laura C Burlage; Sanna Op den Dries; Henri G D Leuvenink; Ton Lisman; Korkut Uygun; James F Markmann; Robert J Porte Journal: J Vis Exp Date: 2015-05-26 Impact factor: 1.355
Authors: Hieu Le Dinh; Arnaud de Roover; Abdour Kaba; Séverine Lauwick; Jean Joris; Jean Delwaide; Pierre Honoré; Michel Meurisse; Olivier Detry Journal: World J Gastroenterol Date: 2012-09-07 Impact factor: 5.742
Authors: Moustafa Mabrouk Mourad; Abdullah Algarni; Christos Liossis; Simon R Bramhall Journal: World J Gastroenterol Date: 2014-05-28 Impact factor: 5.742
Authors: Thomas J Chirichella; C Michael Dunham; Michael A Zimmerman; Elise M Phelan; M Susan Mandell; Kendra D Conzen; Stephen E Kelley; Trevor L Nydam; Thomas E Bak; Igal Kam; Michael E Wachs Journal: World J Gastroenterol Date: 2016-03-28 Impact factor: 5.742