INTRODUCTION: Individuals with neurodevelopmental disorders have been observed to show accelerated cognitive aging or even dementia as early as 30 and 40 years of age. Memory deficits are an important component of age-related cognitive loss. METHODS: In this study, we investigated prospective memory, which is often impaired in aging, in a group of 32 adults with spina bifida meningomyelocele (SBM), including members of the oldest living cohort successfully treated with shunts to divert excess cerebrospinal fluid, ventriculomegaly, and hydrocephalus, who are now around 50 years of age. Seventeen typically developing adults provided a comparison group. RESULTS: The SBM and comparison groups differed in the prospective memory total score as well as in both time-based and event-based subscores. Prospective memory was impaired in both older and younger individuals with SBM. However, the percentage of individuals with impaired or poor prospective memory was three times higher in the older SBM group than in the younger SBM group. The results are considered in relation to specific features of the complex brain reorganization in SBM.
INTRODUCTION: Individuals with neurodevelopmental disorders have been observed to show accelerated cognitive aging or even dementia as early as 30 and 40 years of age. Memory deficits are an important component of age-related cognitive loss. METHODS: In this study, we investigated prospective memory, which is often impaired in aging, in a group of 32 adults with spina bifida meningomyelocele (SBM), including members of the oldest living cohort successfully treated with shunts to divert excess cerebrospinal fluid, ventriculomegaly, and hydrocephalus, who are now around 50 years of age. Seventeen typically developing adults provided a comparison group. RESULTS: The SBM and comparison groups differed in the prospective memory total score as well as in both time-based and event-based subscores. Prospective memory was impaired in both older and younger individuals with SBM. However, the percentage of individuals with impaired or poor prospective memory was three times higher in the older SBM group than in the younger SBM group. The results are considered in relation to specific features of the complex brain reorganization in SBM.
Authors: Jack M Fletcher; Kim Copeland; Jon A Frederick; Susan E Blaser; Larry A Kramer; Hope Northrup; H Julia Hannay; Michael E Brandt; David J Francis; Grace Villarreal; James M Drake; John P Laurent; Irene Townsend; Susan Inwood; Amy Boudousquie; Maureen Dennis Journal: J Neurosurg Date: 2005-04 Impact factor: 5.115
Authors: M A Scott; J M Fletcher; B L Brookshire; K C Davidson; S H Landry; T C Bohan; L A Kramer; M E Brandt; D J Francis Journal: Neuropsychology Date: 1998-10 Impact factor: 3.295
Authors: M Dennis; M S Salman; D Jewell; R Hetherington; B J Spiegler; D L MacGregor; J M Drake; R P Humphreys; F Gentili Journal: Childs Nerv Syst Date: 2009-08-12 Impact factor: 1.475
Authors: Amery Treble-Barna; Jenifer Juranek; Karla K Stuebing; Paul T Cirino; Maureen Dennis; Jack M Fletcher Journal: Neuropsychology Date: 2014-07-28 Impact factor: 3.295
Authors: Sheida Malekpour; Zhimin Li; Bing Leung Patrick Cheung; Eduardo M Castillo; Andrew C Papanicolaou; Larry A Kramer; Jack M Fletcher; Barry D Van Veen Journal: Brain Connect Date: 2012-06-28
Authors: Ashley L Ware; Jenifer Juranek; Victoria J Williams; Paul T Cirino; Maureen Dennis; Jack M Fletcher Journal: Neuroimage Clin Date: 2014-06-02 Impact factor: 4.881