Richard Hughes1. 1. MRC Centre for Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, PO Box 114, Queen Square, London, WC1N 3BG, UK, rhughes11@btinternet.com
Abstract
UNLABELLED: Chronic inflammatory demyelinating polyradiculoneuropathy is a chronic progressive or relapsing and remitting disease with a prevalence of up to 8.9 per 100,000. METHODS: This review discusses possible mechanisms, none of which are proven, and describes the evidence for its treatment. RESULTS: Cochrane Reviews provide evidence that corticosteroids, intravenous immunoglobulin, and plasma exchange are effective short-term treatments. Attempts to confirm the efficacy of other immunosuppressant agents have not been successful, although they are often used in people whose disease is resistant to the first-line treatments. CONCLUSIONS: More and better trials are needed.
UNLABELLED: Chronic inflammatory demyelinating polyradiculoneuropathy is a chronic progressive or relapsing and remitting disease with a prevalence of up to 8.9 per 100,000. METHODS: This review discusses possible mechanisms, none of which are proven, and describes the evidence for its treatment. RESULTS: Cochrane Reviews provide evidence that corticosteroids, intravenous immunoglobulin, and plasma exchange are effective short-term treatments. Attempts to confirm the efficacy of other immunosuppressant agents have not been successful, although they are often used in people whose disease is resistant to the first-line treatments. CONCLUSIONS: More and better trials are needed.
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