Literature DB >> 20393477

Common links among the pathways leading to UV-induced immunosuppression.

Gary M Halliday1.   

Abstract

In this issue, Sreevidya et al. demonstrate unexpected similarities in the downstream events of two molecular triggers of UV-induced immunosuppression. Both platelet-activating factor and cis-urocanic acid produced reactive oxygen species (ROS). Blocking both photoproducts reduced UV-induced genetic damage. Vitamin D, another immunosuppressive photoproduct, does not share this property but instead enhances DNA repair. This study therefore links ROS and genetic damage with two molecular triggers of UV immunosuppression.

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Year:  2010        PMID： 20393477     DOI： 10.1038/jid.2009.374

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  12 in total

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5.  Protective effect of the ethyl acetate fraction of Sargassum muticum against ultraviolet B-irradiated damage in human keratinocytes.

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