Literature DB >> 20393187

Optimal control of blood glucose: the diabetic patient or the machine?

Larry Brown1, Elazer R Edelman.   

Abstract

In this issue of Science Translational Medicine, El-Khatib et al. describe a "closed-loop" bihormonal artificial pancreas, designed to avert episodes of low blood sugar in patients with insulin-dependent diabetes. We discuss the benefits and challenges of therapy directed at tight control of blood glucose and ask whether this and similar technological breakthroughs can address as yet unanswered questions in the biology of diabetes.

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Year:  2010        PMID： 20393187      PMCID： PMC4620569          DOI： 10.1126/scitranslmed.3001083

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  45 in total

1.  The changing face of glucagon fibrillation: structural polymorphism and conformational imprinting.

Authors:  Jesper Søndergaard Pedersen; Dantcho Dikov; James L Flink; Hans Aage Hjuler; Gunna Christiansen; Daniel Erik Otzen
Journal:  J Mol Biol       Date:  2005-11-09       Impact factor: 5.469

2.  Metabolism: food alert.

Authors:  Joshua P Thaler; David E Cummings
Journal:  Nature       Date:  2008-04-24       Impact factor: 49.962

3.  Prolonged insulin independence after islet allotransplants in recipients with type 1 diabetes.

Authors:  M D Bellin; R Kandaswamy; J Parkey; H-J Zhang; B Liu; S H Ihm; J D Ansite; J Witson; P Bansal-Pakala; A N Balamurugan; K K Papas; K Papas; D E R Sutherland; A Moran; B J Hering
Journal:  Am J Transplant       Date:  2008-09-19       Impact factor: 8.086

4.  A bihormonal closed-loop artificial pancreas for type 1 diabetes.

Authors:  Firas H El-Khatib; Steven J Russell; David M Nathan; Robert G Sutherlin; Edward R Damiano
Journal:  Sci Transl Med       Date:  2010-04-14       Impact factor: 17.956

5.  Adjunctive therapy with pramlintide lowers HbA1c without concomitant weight gain and increased risk of severe hypoglycemia in patients with type 1 diabetes approaching glycemic targets.

Authors:  R Ratner; F Whitehouse; M S Fineman; S Strobel; L Shen; D G Maggs; O G Kolterman; C Weyer
Journal:  Exp Clin Endocrinol Diabetes       Date:  2005-04       Impact factor: 2.949

6.  Deleterious effects of increased body weight associated with intensive insulin therapy for type 1 diabetes: increased blood pressure and worsened lipid profile partially negate improvements in life expectancy.

Authors:  Andrew J Palmer; Stéphane Roze; William J Valentine; Michael E Minshall; Morten Lammert; Lars Nicklasson; Giatgen A Spinas
Journal:  Curr Med Res Opin       Date:  2004-08       Impact factor: 2.580

7.  A randomized, prospective trial comparing the efficacy of continuous subcutaneous insulin infusion with multiple daily injections using insulin glargine.

Authors:  Elizabeth A Doyle; Stuart A Weinzimer; Amy T Steffen; Jo Ann H Ahern; Miranda Vincent; William V Tamborlane
Journal:  Diabetes Care       Date:  2004-07       Impact factor: 19.112

8.  Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study.

Authors:  Y Ohkubo; H Kishikawa; E Araki; T Miyata; S Isami; S Motoyoshi; Y Kojima; N Furuyoshi; M Shichiri
Journal:  Diabetes Res Clin Pract       Date:  1995-05       Impact factor: 5.602

9.  A nanoporous, transparent microcontainer for encapsulated islet therapy.

Authors:  Barjor Gimi; Joonbum Kwon; Andrey Kuznetsov; Behroze Vachha; Richard L Magin; Louis H Philipson; Jeong-Bong Lee
Journal:  J Diabetes Sci Technol       Date:  2009-03

10.  Effect of excessive weight gain with intensive therapy of type 1 diabetes on lipid levels and blood pressure: results from the DCCT. Diabetes Control and Complications Trial.

Authors:  J Q Purnell; J E Hokanson; S M Marcovina; M W Steffes; P A Cleary; J D Brunzell
Journal:  JAMA       Date:  1998-07-08       Impact factor: 157.335
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  5 in total

1.  Insulin analogs for the treatment of diabetes mellitus: therapeutic applications of protein engineering.

Authors:  Daniel F Berenson; Allison R Weiss; Zhu-Li Wan; Michael A Weiss
Journal:  Ann N Y Acad Sci       Date:  2012-03-13       Impact factor: 5.691

2.  Switch-based biosensors: a new approach towards real-time, in vivo molecular detection.

Authors:  Kevin W Plaxco; H Tom Soh
Journal:  Trends Biotechnol       Date:  2010-11-23       Impact factor: 19.536

Review 3.  Design of non-standard insulin analogs for the treatment of diabetes mellitus.

Authors:  V Pandyarajan; M A Weiss
Journal:  Curr Diab Rep       Date:  2012-12       Impact factor: 4.810

4.  A reusable electrochemical proximity assay for highly selective, real-time protein quantitation in biological matrices.

Authors:  Jiaming Hu; Yajiao Yu; Jessica C Brooks; Leah A Godwin; Subramaniam Somasundaram; Ferdous Torabinejad; Joonyul Kim; Curtis Shannon; Christopher J Easley
Journal:  J Am Chem Soc       Date:  2014-05-30       Impact factor: 15.419

Review 5.  C-Peptide as a Therapy for Type 1 Diabetes Mellitus.

Authors:  Rachel L Washburn; Karl Mueller; Gurvinder Kaur; Tanir Moreno; Naima Moustaid-Moussa; Latha Ramalingam; Jannette M Dufour
Journal:  Biomedicines       Date:  2021-03-08
  5 in total

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